August 23, 2016

Faculty & Investigators

Roger Albin, MD

Roger AlbinAssociated with the MADC as the Research Education Component Core Leader, Dr. Albin is a Professor of Neurology at the University of Michigan. He held the title of Brain Bank Director at the University of Michigan from 1998 through January of 2016. In addition to caring for patients with cognitive disorders, he studies basic disease mechanisms and participates in human imaging studies seeking to improve our diagnosis of dementing disorders.  He also performs research on brain chemical factors that influence the production of beta-amyloid, a key disease protein in Alzheimer’s disease.  Dr. Albin is passionate about advancing disease knowledge so that we can treat patients better.  He attended medical school at the University of Pittsburgh and received his Neurology training at the University of Michigan.

Nancy Barbas, MD, MSW

nancy_barbas-e1364239437708Associated with the MADC for many years, Dr. Barbas is Associate Professor of Neurology and Director of the Cognitive Disorders Clinic at the University of Michigan Health System. She has been on the faculty of University of Michigan Medical School and Health System since 1991.  Dr. Barbas’s clinical interests include cognitive disorders in adults, such as Alzheimer’s disease and related dementias, and general geriatric neurology. She is active in clinical trial research for treatment development for Alzheimer’s disease and other dementias. She actively trains the next generation of professionals, teaching them state-of-art dementia care techniques and research skills.  She has published articles and chapters on dementia topics. Nan has spent the majority of her years in higher education in Ann Arbor, Michigan obtaining Bachelors of Arts (BA), Masters in Social Work (MSW), and Doctor of Medicine (M.D.) degrees from the University of Michigan. She continued her training at Tufts New England Medical Center in Boston completing a Neurology Residency and a Neuro-ophthalmology Fellowship.

Sami Barmada, MD, PhD

??????????????????????????????????????Dr. Barmada currently serves as Associate Professor of Neurology at the University of Michigan. He was recruited from UCSF to the University of Michigan in 2013.  Dr. Barmada divides his time between the laboratory, Cognitive Disorders Program, and the classroom.  In his investigations of molecular mechanisms in FTD including TDP43 proteinopathies, Dr. Barmada employs automated microscopy.  He treats patients in the Cognitive Disorders Program, with an emphasis on individuals with dementia and motor neuron disease.  Dr. Barmada is also an Assistant Professor of Neurology.

Andrea Bozoki, MD

andreabozokiDr. Andrea Bozoki is an Associate Professor in the Department of Neurology and Department of Radiology at Michigan State University. The focus of her individual scholarship has been the exploration of cognitive function during the transition between healthy aging and early dementia. In particular, she is interested in the structure-function relationships underlying the evolution of de novo Mild Cognitive Impairment and Alzheimer’s disease, as well as understanding what factors can prevent or allay cognitive decline during aging. Her work has utilized primarily neuropsychometric testing along with functional and structural MR imaging. More recently, she has included amyloid and FDG-PET data to examine the relative advantages of using a broader multi-modal imaging approach to biomarker development.

Scott Counts, PhD

scott-countsDr. Counts is an Associate Professor of Translational Science & Molecular Medicine at Michigan State University. The goal of his research is to understand the molecular pathogenic mechanisms of selective neuronal vulnerability in the preclinical and prodromal stages of Alzheimer’s disease (AD). His pre-doctoral training with Dr. Allan Levey at Emory emphasized the importance of combining carefully controlled human tissue research with cellular and molecular modeling to reveal potential pathways underlying AD progression. He is the MSU liaison for the UM ADC Neuropathology Core and Brain Bank. His duties include generating awareness and providing training to MSU investigators in the procurement and use of postmortem tissue and bio-specimens from UM for dementia research. He also serves as the MSU representative to the Brain Bank Tissue Request Committee.

Ivo Dinov, PhD

port-dinov-ivo-2013Ivo Dinov, PhD, is an Associate Professor of Health Systems and Bioinformatics at the University of Michigan. He is also the Director of the National Statistics Online Computational Resource (SOCR). Dr. Dinov is an expert on statistical computing, high-throughput data analytics, analysis of high dimensional imaging datasets, and health science and STEM education. At the MADC, Dr. Dinov will assist in data analytics and statistical modeling efforts. He will also provide expertise in fusion of neuroimaging, clinical, phenotypic and genetics data.

Hiroko Dodge, PhD

hiroko4Dr. Dodge is the Milton and Carolyn Kevreson Research Professor of Neurology and Adjunct Research Associate Professor of Neurology in the University of Michigan Department of Neurology. She is a Fellow in the Gerontological Society of America (GSA). She serves as a statistical editor for Alzheimer’s & Dementia (the official journal of the Alzheimer’s Association) and a senior associate editor for Alzheimer’s & Dementia: Translational Research and Clinical Advancements, a sister journal of Alzheimer’s & Dementia. She also serves on the statistical editorial board for International Psychogeriatrics. Dr. Dodge joined the MADC as the Data Core Leader in 2010. She has been successfully directing two Alzheimer’s Disease Centers’ Biostatistics and Data Cores: the Michigan ADC and the NIA-funded Layton Aging  ADC at Oregon Health & Science University, Portland, Oregon. These dual positions allow her to facilitate collaborations between the two centers. Dr. Dodge’s research interests are diverse and include a) distinguishing normal cognitive aging from pathological cognitive decline, b) testing whether stimulation through social interactions can improve cognitive functions, c) clinical trial methods, and d) examining lifestyle and environmental factors that lead to healthy cognitive aging. A native of Japan, she has a longitudinal cohort in Okinawa, Japan and collaborates with the Okinawa Centenarian Study group.

For more information about Hiroko, visit her webpage here.

Bruno Giordani, PhD

giordaniDr. Giordani is a Chief of Psychology, and a tenured Professor in the Psychiatry, Neurology, and Psychology Departments as well as the School of Nursing. He is a University Faculty Ombuds at the University of Michigan.  Associated with the MADC for over 25 years, Dr. Giordani has a longstanding history of connecting with the community to promote a better understanding of Alzheimer’s disease and related conditions.  He has served on the Executive Board of the Alzheimer’s Association, Michigan Great Lakes Chapter (MGLC) since 2007 and has been both its Board Chair and National Representative, as well as a Steering Committee being a member of the national Association’s Assembly Steering Committee.  His research initiatives focus on a cross-cultural perspective on the early assessment of cognitive and behavioral changes associated with medical illness and the interaction of cognition and mobility across the life-span.  Dr. Giordani completed his MA and PhD in Clinical Psychology at the University of Virginia and received his postdoctoral training in Clinical and Research Neuropsychology at the University of Michigan.

Yuangfang Guan, PhD

yuanfang_guanDr. Guan is Assistant Professor in the Department of Computational Medicine & Bioinformatics at the University of Michigan. She received her PhD training in functional genomics at Princeton University followed by a brief postdoctoral fellowship, also at Princeton. In 2011, she joined the University of Michigan where her research as an independent investigator focused on developing generic, first-principle computational solutions to large-scale biomedical data. She has created seven best-performing algorithms in the past three years, breaking the record of DREAM’s (Dialogue of Reverse Engineering and Methods) 10 years of history. She has best-performing algorithms in areas such as population genetics, DNA variation, transcriptome data, proteomic data, medical imaging, biochemical structures, cancer, rheumatoid arthritis, and most notably, Alzheimer’s Disease and cognitive impairment.

Mark Haacke, PhD

markDr. Haacke is an original pioneer of MR angiographic imaging, fast imaging and cardiovascular imaging, and more recently has developed a powerful new method for imaging veins, micro-hemorrhaging and iron called Susceptibility Weighted Imaging (SWI). His research has focused on studying the role of magnetic field variations in the human body and applying the results to clinical translational research. SWI may in fact become an important biomarker not just for different forms of iron but in investigating the etiology of a number of key diseases such as aging, multiple sclerosis, stroke and trauma. More recently his work has focused on extending SWI to quantitative susceptibility mapping (QSM) as a means to map iron and oxygen saturation.

Benjamin Hampstead, PhD, ABPP/CN


Dr. Hampstead joined the U-M faculty in September 2014 as an Associate Professor in Psychiatry and Staff Neuropsychologist in the Ann Arbor VA Healthcare System. He is the Clinical Core Leader at the MADC.  Dr. Hampstead is an expert in functional imaging and nonpharmacological approaches to enhance age-related memory function (e.g., cognitive rehabilitation and direct brain stimulation). Through his appointment in the Ann Arbor VA Healthcare System, he is well-positioned to ensure that our older veterans have access to cutting-edge research and clinical procedures.

Judy Heidebrink, MD, MS

judy_heidebrink-e1366663002363Dr. Heidebrink is a Richard D. and Katherine M. O’Connor Research Professor and has been affiliated with the Michigan Alzheimer’s Disease Center since 1995, when she began her fellowship training in Geriatric Neurology.  She is also the Director of the Cognitive Disorders Clinic at the University of Michigan.  Her clinical and research interests focus on improving the diagnosis and treatment of Alzheimer’s disease and related disorders.  Dr. Heidebrink leads the University of Michigan’s participation in the Alzheimer’s Disease Neuroimaging Initiative (ADNI).  This landmark study uses brain imaging and other biomarkers to evaluate the onset and progression of Alzheimer’s disease.  ADNI data support the belief that brain changes occur many years before symptoms of Alzheimer’s disease emerge.  ADNI techniques will soon be used to identify persons with very early Alzheimer’s pathology, in order to study therapies that might halt the disease even before symptoms appear.  Judy attended medical school at the University of Texas Southwestern and received her Neurology training at the University of Michigan.

Joan Ilardo, PhD

joanDr. Ilardo is the Director of the Research Initiatives at the Michigan State University College of Human Medicine’s Office of Research and the Co-Director of the Geriatric Education Center of Michigan. As the Executive Director of the Michigan Aging Education Collaborative she interacts with all the major players in the aging network throughout Michigan on a regular basis. She currently has a leadership role in several statewide initiatives related to sustaining and scaling up evidenced-based educational programs in self-management (Stanford CDSMP model), caregiver training (dementia), and advance care planning. As a member of the Michigan Commission on Services to the Aging, she serves on a 15-member commission that oversees Michigan’s implementation of the Older Americans Act through the state aging unit (Michigan Aging and Adult Services Agency) and has access to government officials and legislators involved in aging policy and services in Michigan.

Robert Koeppe, PhD

rad_koeppe_bobDr. Koeppe is a Professor of Radiology at the University of Michigan and the Director of the PET Physics Section of the Division of Nuclear Medicine. His research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.

Kenneth Langa, MD, PhD

Dr. Langa is a Professor in the Department of Internal Medicine, a Research Investigator in the Ann Arbor Veterans Affairs HSR&D Center, a Faculty Associate at the Institute for Social Research, and Social Research, Director of the Institute of Gerontology, at the University of Michigan. He is a Co-Investigator for the Health and Retirement Study (HRS), a National Institute on Aging funded longitudinal study of 20,000 adults in the United States. He is also Lead Investigator for the Aging, Demographics, and Memory Study (ADAMS), a supplemental study to the HRS regarding the risk factors, epidemiology, and outcomes of dementia. He is the recipient of a Career Development Award and R01 grants from the National Institute on Aging, a Paul Beeson Physician Faculty Scholars in Aging Research Award, and a New Investigator Award from the Alzheimer's Association. In 2007, Dr. Langa was a visiting Professor in the Department of Psychiatry and Institute of Public Health at Cambridge University in Cambridge, England.

Peter Lichtenberg, PhD

????????????????????????????????????Dr. Lichtenberg is the Research Education Component Core Co-Leader of the MADC, the director of the Wayne State University Institute of Gerontology, and Co-Director of the Michigan Center for Urban African American Aging Research (MCUAAAR).  He is an expert in Geriatric Psychology and a national leader in addressing health disparities in elderly minority populations. In his role at Wayne State University, Dr. Lichtenberg has founded the IOG pre-doctoral training program in aging and urban health, was the Principle Investigator on a National Institute of Aging training grant from 2001-2012, and has helped train nearly fifty doctoral students in an intensive aging research program. As the MADC Clinical Core Co-Leader, Peter has been instrumental in the MADC’s success with recruiting underrepresented minorities in Detroit.

Andrew Lieberman, MD, PhD

andy_liebermanDr. Lieberman is MADC Neuropathology Core Leader, Abrams Collegiate Professor of Pathology, and Director of Neuropathology at the University of Michigan.  He is internationally known for his research on the mechanism of inherited degenerative brain disorders.  He is passionate about understanding how brain cells “handle” the abnormal proteins that accumulate in so many brain diseases including the dementias, so that we can design rational approaches to therapy.  Dr. Lieberman received his MD and PhD degrees from the University of Maryland Medical School, and completed residency training in Anatomic Pathology and fellowship training in Neuropathology at the University of Pennsylvania.

Henry Paulson, MD, PhD

henry_paulsonDr. Paulson directs the MADC, working closely with MADC staff to define and implement the diverse initiatives through which we fulfill our three-part mission.  Dr. Paulson is also a Lucile Groff Professor of Neurology at the University of Michigan. He joined the Center as Associate Director in 2009 and assumed Directorship in 2011. He has worked for more than 20 years on degenerative brain diseases, both inherited and acquired. As a neurologist and neuroscientist, Dr. Paulson is deeply committed to translating findings from the research bench to the patient bedside. Toward that goal, he is focused on building connections between scientists, clinicians and the public, not only across the U-M campus but also across the state of Michigan. He received his MD and PhD degrees from Yale University School of Medicine and his Neurology training at the University of Pennsylvania.

Carol Persad, PhD

persad-600w-webDr. Persad is the Director of the Neuropsychology Clinic at the University of Michigan. This clinic conducts neuropsychological assessments on over 3,000 patents a year with a range of medical, psychiatric and neurological disorders across the lifespan, and houses a large accredited postdoctoral fellowship training program.

Scott Roberts, PhD

scott_robertsScott Roberts, PhD, is an Associate Professor of Health Behavior and Health Education at the U-M School of Public Health, where he directs its certificate program in Public Health Genetics and co-directs a dual master’s degree program in Public Health and Genetic Counseling. Dr. Roberts conducts research related to health education and support services in AD and has served since 2001 as Co-PI of the NIH-funded REVEAL Study, a NIH-funded series of randomized clinical trials evaluating the impact of disclosing genetic risk information to individuals with a family history of AD. Prior to coming to U-M, Dr. Roberts served as Co-Director of the Education Core in the NIA-funded Boston University Alzheimer’s Disease Center. He now directs the MADC Outreach, Recruitment and Education Core.

Peter K Todd, MD, PhD

Location portraits of Roman Giger, Dr. Ken Casey, Dr. Peter Todd, Dr. William Dauer, Sokol Todi, Dr. Tiffany Braley, Dr. Daniel Leventhal, Dr. Vikram Shokkotai, and Edgar Rodriguez in the BSRB (atrium and fourth floor Paulson lab) on 12/16/09.

An Assistant Professor of Neurology and the Bucky and Patti Harris Collegiate Professor in Alzheimer’s disease at the University of Michigan, Dr. Todd explores the molecular mechanisms in neurodegenerative diseases with a particular interest in repeat expansion diseases such as the recently discovered C9ORF72 expansion underlying frontotemporal dementia. Dr. Todd is also a staff neurologist at the Ann Arbor VA Medical Center. He has worked in the field of Fragile X research for almost 20 years.

Jieping Ye, PhD

ye2Dr. Ye is an Associate Professor of Computational Medicine and Bioinformatics at the University of Michigan. For the last thirteen years, he has been conducting fundamental research in machine learning and data mining, developing computational methods for biomedical data analysis, and building informatics software. He leads the development of the SLEP (Sparse Learning with Efficient Projections) package, which includes implementations of large-scale sparse learning models, and the MALSAR (Multi-tAsk Learning via StructurAl Regularization) package, which includes implementations of state-of-the-art multi-task learning models. Currently, there are about 4,500 active users from over 25 different countries. With close collaboration with researchers at the biomedical field, he has successfully applied these methods for analyzing biomedical data, including clinical image data and genotype data from Alzheimer’s patients.

Deborah Levine, MD, MPH

Dr. Levine’s research aims to improve the lives and care of adults with chronic disease. Primary research interests are the epidemiology, prevention, and care of stroke and cognitive impairment, with a focus on vascular risk factors, adherence, and health disparities. Her research includes improving the quality of stroke care; stroke-related dementia and cognitive impairment; and reducing healthcare disparities in cardiovascular disease and stroke. She also focuses on quality improvement program design, implementation and evaluation research, and research on provider behavior. Some of her research is examining cognitive outcomes after stroke, seeking to understand the predictors and long-term trajectory of cognitive decline after stroke.

Navid Seraji-Bozorgzad, MD

After completing his undergraduate degree in physics from the University of Michigan, Navid Seraji joined the Wayne State community as a research assistant in the Brain Imaging Laboratory in 1998. He was accepted into the Neuroscience graduate program and continued work on high field Magnetic Resonance Spectroscopy. He graduated from WSU medical school in 2007, and after completing his Internal Medicine and Neurology residency he joined the Neurology department as a neurohospitalist in 2013. As a neurohospitalist, his clinical duties include hospital care of neurology patients. He is also involved in quality control measures, and whole patient care both in the hospital, and after discharge. The interaction of body and brain in disease state are of particular interest to him, both in terms of neurological manifestations of systemic disease, and effect of neurological disease on other systems. His research experience is in the field of MR imaging. He is interested in biomarkers of brain injury and repair, as it applies to various degenerative disorders, including Alzheimers disease. Dr. Seraji is involved in the resident education programs, including development of interactive curriculum suited to adult learning. He also instructs the residents in evidence-based medicine, and runs the resident journal club.

Kevin Jones, PhD

Dr. Jones received his PhD from Duke University Medical School and completed a Postdoctoral Fellowship at the Ramon y Cajal Institute, Department of Neural Plasticity in Madrid, Spain. He was also an Assistant Professor at Western University of Health Sciences, College of Osteopathic Medicine of the Pacific, Department of Basic Medical Sciences and a Postdoctoral Fellow at the Center for Neuroscience in the Children’s Research Institute, Wash, DC. He is currently an Assistant Professor of Biology at Howard University in Washington, DC.

The goal of the Jones Lab is to identify novel therapeutic approaches to improve iGluR dysfunction. Dysfunctional neurotransmission through iGluRs contribute to the pathophysiology of many psychiatric and neurological disorders. Recent evidence suggests expression of the iGluR subunit, GluA4, may be dramatically reduced in Alzheimer's Disease (AD) patients (Xiao et al., 2017). The Jones lab is interested in replicating the findings of Xiao et al. Specifically, they wish to
compare the expression of GluA4 in tissue samples of controls and AD patients from the University of Michigan Brain Bank.