August 22, 2016

For Professionals

  • Need Help with Recruitment?

    The MADC promotes clinical research on memory and aging that involves direct use of research volunteers, biomarkers, and other clinical data collected through the University of Michigan Memory and Aging Project (UM-MAP).  The MADC manages a well-characterized dataset to facilitate recruitment for MADC-supported projects and publications.

    Clinical Resource Application

    Investigators wishing to utilize the research volunteer database must complete the MADC Clinical Resource Application (PDF).

    Data Requests

    Do we have the resources you are looking for?  For preliminary data requests, please complete and submit the MADC Data Request form (PDF).

    For more information, contact Arijit Bhaumik, 734-936-8281 or arijit@med.umich.edu.

    Acknowledgement and Logos

    Please remember to acknowledge partial support from NIH/NIA grant P30AG053760 in your publications, presentations, web-sites, posters, and other dissemination efforts that are related to MADC research, development and training activities and also include an approved MADC logo.

    Text must read:

    This <project/study (choose one)> was partially supported by the NIH/NIA funded Michigan Alzheimer’s Disease Center (P30AG053760).

    Logos:

    For approved MADC logos to use in posters and presentations, please contact:

    Arijit Bhaumik – arijit@med.umich.edu

    Nancy Laracey – laracey@med.umich.edu

    Renee Gadwa – rgadwa@med.umich.edu

  • The MADC Pilot Project Program

    As we seek to understand and cure AD and related dementias, the MADC considers it among our highest priorities to support innovative, high impact research. The MADC Pilot Project Program provides “kick-starter” funds to U-M investigators so that they can begin testing new ideas about the causes and treatment of dementias. The MADC is committed to funding $35,000 pilot projects per year, open to any investigators at UM, MSU, WSU and Ann Arbor VA.

    2016 Pilot Projects

    Apply for a Pilot Project

    DEADLINE EXTENDED through January 6, 2017

    All Applicants can apply through this Application Portal

    • Internal Submission Deadline: Friday, Jaunary 6, 2017
    • Award Cycle: 2017
    • Discipline/Subject Area: Neurology
    • Funding Available: 35,000.00
    • Description:

     

    As we seek to understand and cure Alzheimer' disease (AD) and related dementias, the University of Michigan Alzheimer's Disease Center (MADC) considers it among our highest priorities to support innovative, high impact research. The MADC Pilot Project Program is partially supported by the Alzheimer's Disease Core Center (ADCC) linking the University of Michigan, Michigan State University and Wayne State University. The ADCC’s central theme focuses on identifying, understanding and modulating the numerous non-β-amyloid factors that contribute to brain dysfunction and neurodegeneration. The MADC Pilot Project Program provides “kick-starter” funds to University of Michigan (UM), Michigan State University (MSU), Wayne State University (WSU), and Veteran Affairs Ann Arbor Health System (VAAAHS) investigators to test new ideas about the causes and treatment of dementing disorders. Pilot projects should emphasize one or more of the following:

      • Center’s thematic focus on non-beta amyloid factors contributing to neuronal dysfunction and degeneration in dementia
      • Leveraging of resources available at the MADC and its Cores and co-enrollment of participants in the MADC’s longitudinal cohort
      • Utilization of databases available at the MADC, the Michigan Brain Bank via the MADC Neuropathology Core, the National Alzheimer's Coordinating Center (NACC), or the Alzheimer’s Diseases Neuroimaging Initiative (ADNI)
      • Novel methods of detecting/treating cognitive changes
      • Emphasis on studying cognition and unique challenges to diagnosing and treating age-related dementia in underrepresented minorities
      • Focus on aging, frailty and cognitive changes due to aging in older adults

     

    The MADC is committed to funding two pilot projects this year, open to any investigator at the three Universities (UM, MSU & WSU). The MADC invites members of the scientific community from these partner institutions to submit applications for pilot project funding. The proposed research must be relevant to Alzheimer's disease and/or non-amyloid related dementias. We anticipate funding at least two $35,000 (direct cost only) projects for a period of one year, beginning 02/1/17 and ending 01/31/18.

    We encourage UM/MSU/WSU investigators at all levels to apply. Applications received from junior investigators, established investigators new to Alzheimer’s disease or dementia research, and investigators who have not previously received pilot project funding through the MADC, will be looked upon most favorably. Emphasis will also be given to projects that link researchers from multidisciplinary fields and across the Universities. Applications should be no more than three pages in length, and describe research commensurate with a one year award. Reviewers will rank proposals based on their potential significance and impact, investigator and investigative team, research plan, likelihood of leading to future NIH or private foundation funding, relevance to AD and related dementias, and relevance to the MADC’s thematic focus on non-amyloid factors. Applications are due by January 6, 2017.

    Successful applicants will be required to provide a six month progress report and a final end-of-year report and presentation to the MADC Executive Committee. At the end of the funding period or soon thereafter, the MADC is looking to see one or more publications as a result of the pilot project, and/or continued funding in the form of a new R01 or equivalent grant.

    The award can be used for the direct support of salary and/or supplies (no indirect support is allowed). No tuition support is available. Equipment in excess of $5000 needs special justification and is generally not encouraged.

    Submission: Applications should be submitted through the University of Michigan Medical School Office of Research Competition Space portal: https://umms.infoready4.com/#homePage

    Three page proposals that include a specific aims section are due by Friday, January 6, 2017. Budget and budget justification, biosketch in NIH format, and other support documents are also due at this time.

    Biosketch, budget/budget justification, and other support templates are provided in the Competition Space. Start date is expected to be February 1, 2017, but is somewhat flexible.

    Note: Any project involving animal or human samples must provide proof of IACUC or IRB approval prior to initiation of the project. If this is not obtained within 60 days of the funding date for the project, funding will be withdrawn.

    For questions please contact Arijit Bhaumik at 734-936-8281, email: arijit@umich.edu

    2014-2015 Funded Pilot Projects

    “Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive Impairment (MCI)”

    Deborah A. Levine, MD, MPH
    Assistant Professor of Internal Medicine and Assistant Professor of Neurology

    levinedeborahmdsm

    Goal: to develop, test, and disseminate strategies to improve the care and clinical decision-making of older patients with MCI

    Outcome: One publication. Data were incorporated into an R01 grant application with Dr. Levine as PI (submitted October 2015).

    “Screening for novel G4C2 hexanucleotide repeat expansions in neurodegenerative disease”

    Peter K Todd, MD, PhD
    Harris Career Development Professor of Neurology

    Peter Todd

    Goal: To identify novel hexanucleotide repeat expansions as a first step in establishing their roles in the biology of dementia

    Outcome: Project is ongoing; has led to a new collaboration with Deborah Hall, MD, or Rush ADC.

    “Novel approaches to measuring and facilitating the clearance of soluble amyloid from the brain”

    Vikas Kotagal, MD, MS
    Assistant Professor of Neurology

    Goal: To test the primary hypothesis that scalp cooling facilitates the glymphatic system and enhances clearance of soluble A-beta.

    Outcome: Project is ongoing. No publications yet. Kotagal acquired a mentored VA grant this year.

    “Reducing subjective memory complaints in older adults through non-invasive brain stimulation”

    Benjamin Hampstead, PhD
    Associate Professor of Psychiatry, Neuropsychology Section

    bhampste-1

    Goal: To examine whether tDCS can reduce the severity of SMCs and improve memory test performance in older adults with such complaints.

    Outcome: Project is ongoing.

  • brain-bank-long


    The Michigan Brain Bank is designed to support investigations of dementing disorders.  The Brain Bank provides researchers who study AD and related disorders with access to well-characterized human brain tissue. To optimize research, the Brain Bank assists in the collection and storage of brain tissue from individuals who have been followed in research studies at the University of Michigan and other centers. We are fortunate to have had many generous patients and families participate in this brain donation program. The most useful tissue for research comes from individuals with extensive clinical information, typically from those who have participated in clinical research projects. Tissues stored in the MADC Brain Bank are extensively characterized by experienced pathologists and available to scientists on request.  Brain Bank tissues have been used by numerous scientists here and at other centers in the USA.

    For investigators wishing to utilize tissues stored in the Michigan Brain Bank, please visit the Michigan Brain Bank website to download and submit tissue resource applications.  Investigators may also download the Tissue Resource Application and submit it via mail.

    For further information, please contact Matthew Perkins at UMHSbrainbank@med.umich.edu or 734-647-7648.