July 12, 2016

Research

  •  join-a-study

    The Michigan Alzheimer’s Disease Center conducts and supports innovative memory and aging research that seeks to:

    • identify disease modifying treatments
    • understand disease mechanisms in AD and other dementias
    • define biomarkers for early and accurate detection
    • devise effective coping strategies for individuals with memory loss and their care-partners
      .

    Despite tremendous recent advances in understanding Alzheimer’s disease and related dementias, there’s still much we do not know about the causes of dementing disorders and how to slow down or prevent them altogether.  Clinicians and scientists alike need to take a broad, fresh view of the causes of dementia and the potential routes to better therapy.  The MADC is deeply committed to this task. Building from the rich expertise present across the University campus, the MADC strives to foster cutting-edge research toward a better understanding and better treatment of Alzheimer’s disease, Lewy Body Disease, frontotemporal dementia and other related disorders.

    Areas of research emphasis include investigations of the quality control machinery that counters aggregated proteins in dementia, imaging studies that seek to improve our ability to diagnose disease earlier and more accurately, and explorations of the interplay between metabolic disorders (e.g. obesity, diabetes) and Alzheimer’s disease.  A key part of the MADC mission is to make connections – linking scientists to scientists, clinicians to scientists, volunteers to studies, even programs to programs.  Through these connections, we can lower the barriers to solving the challenging problems associated with dementia.

  • Drug Treatment Studies

     

    RVT-101

    bohnennicolaas_advertisement_flyerThis is a Phase 2, double-blind, randomized, placebo-controlled crossover study evaluating the effect of RVT-101 on gait and balance in people with Alzheimer’s disease, Lewy body dementia, or Parkinson’s disease dementia ages 55 to 89. Contact Christine Minderovic at cmindero@med.umich.edu or 734-998-8420 or Francesca Picotte at fpicotte@med.umich.edu  or 734-998-8400. 


    Brain Stimulation Studies

    Promoting adaptive neuroplasticity in mild cognitive impairment (Merit)

    NeuroRehabilitation Study



    Neuroimaging and Biomarker Studies

    Examination of the earliest symptoms and biomarkers of FTLD MAPT carriers

    Investigating the earliest clinical features of frontotemporal dementia in an effort to improve early detection of the disease.  Study is looking for adults age 18 and older with a family member who has frontotemporal dementia.  Contact Stephen Campbell at stepcamp@med.umich.edu or 734-763-2361.

    Risk Evaluation and Education of Alzheimer’s Disease – the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)



    Lifestyle Intervention Studies

    University of Michigan Memory and Aging Project (UM-MAP)

    Investigating changes in cognitive functioning over time to learn more about normal aging and neurodegenerative diseases. Study is looking for adults with or without cognitive changes over the age of 55.  Contact Stephen Campbell at stepcamp@med.umich.edu or 734-763-2361.

    Community Urban Electroencephalography Study (CUES)

    Mind ‘n MOTION

    Enhancing Safe Mobility among Older Drivers

    Investigating how older drivers might change their driving behavior over time and what influences any changes that might occur.  Study is looking for healthy adults age 65 or older.  Contact Jennifer Zakrajsek at jzak@umich.edu or 734-615-4740.

    ACT-OUT (Participation in ACTivities and Places OUTside the Home of Older Adults with Dementia)

    This study takes place at Wayne State University and is investigating participation in activities and places outside the home of older adults with dementia to examine what people do and where they participate in everyday life as they age.  This study involves completing a survey and answering interview questions.  The study is looking for adults over the age of 55 who are living with dementia.  Contact Susan Lawrence, PhD at susan.lawrence2@wayne.edu or 313-577-1217

    Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive Impairment (MCI DeM)

     

     

     

     

     

    Investigating what adults with cognitive impairment and the friends or family involved in medical care think about health risks and preferences for medical treatment if they were to become seriously ill because of a heart attack or stroke.  Study is looking for adults age 65 or older who have a diagnosis of mild cognitive impairment and are fluent in English.  Contact Bailey Green at greenba@med.umich.edu or 734-647-3971.


  • Join a Study

    Now is the time to join our research team. Research participation is a generous gift – a gift that can be shared with future generations as we pave the way to new discoveries in treatment and prevention.

    Research participation contributes to the discovery of new ways to diagnose, treat and support people with Alzheimer’s disease or a related disorder. The University of Michigan Memory and Aging Project (UM-MAP), our primary memory and aging study at the MADC, aims to enhance our understanding of the earliest signs of memory or thinking changes. This study simply evaluates naturally occurring changes in behavior and health status of research volunteers over a period of time. Once you are enrolled in UM-MAP, our study coordinator can connect you to other observational, imaging and clinical drug trials that best fit your interests and needs.

    We are currently seeking research volunteers experiencing early signs of memory changes as well as healthy older adults. We understand that participating in research is not always an easy decision. Individuals and their families should carefully consider all of the possible benefits and risks before agreeing to participate.

    If you are interested in participating in research, please complete a Research Volunteer Form and mail or email to stepcamp@umich.edu.

    Please contact Stephen Campbell at 734-763-2361 with any questions or concerns.

  • brain-bank-long


    image sizeThere are over 13 million Americans living with a brain disease or disorder. To find treatments and cures, researchers must study the human brain. The Michigan Brain Bank provides individuals and families an opportunity to contribute to this research effort.

    Donated brains are collected and stored by the Michigan Brain Bank to help scientists around the world advance the understanding of brain disease and disorders. You can make a difference and help future generations by generously donating your brain to the Michigan Brain Bank.

    If you are interested in donating to the Michigan Brain Bank or would like more information, please call 734-647-7648 or visit the Michigan Brain Bank website.

     

     

  • Publications

    2017

    Ryan KA, Hammers D, DeLeon A, Bilen H, Frey K, Burke J, Albin R, Barbas N, Heidebrink J, Giordani B. Agreement among neuropsychological and behavioral data and PiB findings in diagnosing Frontotemporal Dementia. J Clin Neurosci. 2017 Jun 7. pii: S0967-5868(17)30253-9. doi: 10.1016/j.jocn.2017.05.008. PMID: 28601570

    Ma X, Bai Y, Lin Y, Hong X, Liu T, Ma L, Haacke EM, Zhou J, Wang J, Wang M. Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging.  Sci Rep. 2017 Apr 4;7:45696. doi: 10.1038/srep45696. PMID:28374764 PMCID:PMC5379544

    Basal LA, Yan Y, Shen Y, Haacke EM, Mehrmohammadi M, Allen MJ.Oxidation-Responsive, EuII/III-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging. ACS Omega. 2017 Mar 31;2(3):800-805. doi: 10.1021/acsomega.6b00514. Epub 2017 Mar 6. PMID:28393130 PMCID:PMC5377279

    Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, *Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017 Mar 21;14(3):e1002254. doi: 10.1371/journal.pmed.1002254. eCollection 2017 Mar.PMID:28323826  PMCID:PMC5360223

    Larson EB, Langa KM. What's the "Take Home" from Research on Dementia Trends? PLoS Med. 2017 Mar 7;14(3):e1002236. doi: 10.1371/journal.pmed.1002236. eCollection 2017 Mar.  PMID:28267775 PMCID:PMC5340344

    Gardner RC, Langa KM, Yaffe K.Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study. PLoS Med. 2017 Mar 7;14(3):e1002246. doi: 10.1371/journal.pmed.1002246. eCollection 2017 Mar.PMID:28267747 PMCID:PMC5340352

    Maust DT, Langa KM, Blow FC, Kales HC. Psychotropic use and associated neuropsychiatric symptoms among patients with dementia in the USA. Int J Geriatr Psychiatry. 2017 Feb;32(2):164-174. doi: 10.1002/gps.4452. PMID:26889640 PMCID: PMC4990518

    Lindauer A, Seelye A, Lyons B, *Dodge HH, Mattek N, Mincks K, Kaye J, Erten-Lyons D.Dementia Care Comes Home: Patient and Caregiver Assessment via Telemedicine.Gerontologist. 2017 Feb 3. doi: 10.1093/geront/gnw206.  PMID:28158415  PMID:PMC5217478

    Gupta R, Lan M, Mojsilovic-Petrovic J, Choi WH, Safren N, Barmada S, Lee MJ, Kalb R.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded <i>C9ORF72</i> Inhibits the Proteasome. eNeuro. 2017 Jan 31;4(1). pii: ENEURO.0249-16.2017. doi: 10.1523/ENEURO.0249-16.2017. eCollection 2017 Jan-Feb.PMID:28197542 PMCID: PMC5282547

    Dodge HH, Zhu J, Hughes TF, Snitz BE, Chang CH, Jacobsen EP, Ganguli M. Cohort effects in verbal memory function and practice effects: a population-based study.Int Psychogeriatr. 2017 Jan;29(1):137-148. doi: 10.1017/S1041610216001551. Epub 2016 Oct 11.PMID:27725002 PMCID:PMC5177461

    Kelly SC, He B, Perez SE, Ginsberg SD, Mufson EJ, Counts SE. Acta Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease. Neuropathol Commun. 2017 Jan 21;5(1):8. doi: 10.1186/s40478-017-0411-2.PMID:28109312 PMCID:PMC5251221

    Counts SE, Ikonomovic MD, Mercado N, Vega IE, Mufson EJ.Biomarkers for the Early Detection and Progression of Alzheimer's Disease.Neurotherapeutics. 2017 Jan;14(1):35-53. doi: 10.1007/s13311-016-0481-z. Review.PMID:27738903 PMCID: PMC5233625

    Langa KM, Larson EB, Crimmins EM, Faul JD, Levine DA, Kabeto MU, Weir DR. A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012. JAMA Intern Med. 2017 Jan 1;177(1):51-58. doi: 10.1001/jamainternmed.2016.6807. PMID:27893041 PMCID: PMC5195883

    McKay, E and Counts, SE. Multi-infarct dementia: a historical perspective. (2017).  Dementia and geriatric cognitive disorders extra (In press). Dement Geriatr Cogn Dis Extra

    Lichtenberg, P.A. Teresi, J.A., Ocepek-Welikson, K & Eimick, J. Reliability and validity of the Lichtenberg Financial Decision Screening Scale (In press).  Innovation in Aging

    2016

         Dodge HH, Zhu J, Woltjer R, Nelson PT, Bennett DA, Cairns NJ, Fardo DW, Kaye JA, Lyons DE, Mattek N, Schneider JA, Silbert LC, Xiong C, Yu L, Schmitt FA, Kryscio RJ, Abner EL. Risk of incident clinical diagnosis of Alzheimer’s disease-type dementia attributable to pathology-confirmed vascular disease.; SMART data consortium. Alzheimers Dement. 2016 Dec 23. pii: S1552-5260(16)33091-6. doi: 10.1016/j.jalz.2016.11.003. [Epub ahead of print] ]PMID: 28017827

    Krans A, Kearse MG, Todd PK.Repeat-associated non-AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome. Ann Neurol. 2016 Dec;80(6):871-881. doi: 10.1002/ana.24800. Epub 2016 Nov 26. PMID:27761921 PMCID:PMC5177492

    Chun SY, Rodriguez CM, Todd PK, Mills RESPECtre: a spectral coherence—based classifier of actively translated transcripts from ribosome profiling sequence data. BMC Bioinformatics. 2016 Nov 25;17(1):482. PMID:27884106 PMCID:PMC5123373

    Flores BN, Dulchavsky ME, Krans A, Sawaya MR, *Paulson HL, Todd PK, Barmada SJ, Ivanova MIDistinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.PLoS One. 2016 Oct 24;11(10):e0165084. doi: 10.1371/journal.pone.0165084.PMID:27776165 PMCID:PMC5077081

    Amiri S, *Dinov ID.  Comparison of genomic data via statistical distribution.J Theor Biol. 2016 Oct 21;407:318-27. doi: 10.1016/j.jtbi.2016.07.032 PMID:27460589 PMCID: PMC5361063

    Dodge HH, Zhu J, Hughes TF, Snitz BE, Chang CH, Jacobsen EP, Ganguli M.Cohort effects in verbal memory function and practice effects: a population-based study.* Int Psychogeriatr. 2017 Jan;29(1):137-148. doi: 10.1017/S1041610216001551. Epub 2016 Oct 11.PMID:27725002 PMCID:PMC5177461

    Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T, Mourdoukoutas AP, Kronberg G, Truong D, Boggio P, Brunoni AR, Charvet L, Fregni F, Fritsch B, Gillick B, Hamilton RH, *Hampstead BM, Jankord R, Kirton A, Knotkova H, Liebetanz D, Liu A, Loo C, Nitsche MA, Reis J, Richardson JD, Rotenberg A, Turkeltaub PE, Woods AJ. Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016. Brain Stimul. 2016 Sep-Oct;9(5):641-61. doi: 10.1016/j.brs.2016.06.004. Review. PMID:27372845 PMCID:PMC5007190

    Zhu F, Panwar B, *Dodge HH, Li H, *Hampstead BM, *Albin RL,* Paulson HL, Guan, Y.COMPASS: A computational model to predict changes in MMSE scores 24-months after initial assessment of Alzheimer's disease.  Sci Rep. 2016 Oct 5;6:34567. doi: 10.1038/srep34567.PMID: 27703197 PMCID: PMC5050516

    Zhang J, Shi J, Stonnington C, Li Q, Gutman BA, Chen K, Reiman EM, Caselli RJ, Thompson PM, Ye J, Wang Y. Hyperbolic Space Sparse Coding with Its Application on Prediction of Alzheimer's Disease in Mild Cognitive Impairment.  Med Image Comput Comput Assist Interv. 2016 Oct;9900:326-334. doi: 10.1007/978-3-319-46720-7_38. PMID:28066843 PMCID: PMC5217478

    Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TLCorrection: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. ; Dominantly Inherited Alzheimer Network..PLoS One. 2016 Sep 20;11(9):e0163669. doi: 10.1371/journal.pone.0163669.PMID:27649320 PMCID: PMC5029931

    Mufson EJ, Ikonomovic MD, Counts SE, Perez SE, Malek-Ahmadi M, Scheff SW, Ginsberg SD. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behav Brain Res. 2016 Sep 15;311:54-69. doi: 10.1016/j.bbr.2016.05.030. Review.PMID:27185734 PMCID: PMC4931948

    Gawronski KA, Kim ES, Langa KM, Kubzansky LD. Dispositional Optimism and Incidence of Cognitive Impairment in Older Adults.Psychosom Med. 2016 Sep;78(7):819-28. doi: 10.1097/PSY.0000000000000345.PMID:27284699 PMCID: PMC5349707

    Díaz-Venegas C, Downer B, Langa KM, Wong R. Racial and ethnic differences in cognitive function among older adults in the USA.Int J Geriatr Psychiatry. 2016. Sep;31(9):1004-12. doi: 10.1002/gps.4410.PMID:26766788 PMCID: PMC4945484

    Promjunyakul NO, Lahna DL, Kaye JA, *Dodge HH, Erten-Lyons D, Rooney WD, Silbert LC.Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities: A multi-modal magnetic resonance imaging study.  J Cereb Blood Flow Metab. 2016 Sep;36(9):1528-36. doi: 10.1177/0271678X16651268. Epub 2016 Jun 7.PMID:27270266 PMCID:PMC5010096

    Reams N, Eckner JT, Almeida AA, Aagesen AL, *Giordani B, *Paulson H, Lorincz MT, Kutcher JS. A clinical approach to the diagnosis of traumatic encephalopathy syndrome: A review.  Journal of the American Medical Association: Neurology. 73(6):734-749, 2016. PMID: 27111824 PMCID:PMC4922002

    2015

    Gabel NM, Crane NA, Avery ET, Kay RE, Laurent A, Giordani B, Alexander NB, Weisenbach SL. Dual-tasking gait variability and cognition in late-life depression. Int J Geriatr Psychiatry. 2015 Nov;30(11):1120-8. doi: 10.1002/gps.4340. PMID: 26251013

    Albin RL, Fisher-Hubbard A, Shanmugasundaram K, Koeppe RA, Burke JF, Camelo-Piragua S, Lieberman AP, Giordani B, Frey KA. Post-mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications. Ann Neurol. 2015 Nov;78(5):824-30. doi: 10.1002/ana.24481. PMID:26183692 PMCID:PMC4836870

    Mufson EJ, Mahady L, Waters D, Counts SE, Perez SE, DeKosky ST, Ginsberg SD, Ikonomovic MD, Scheff SW, Binder L. Hippocampal plasticity during the progression of Alzheimer’s disease. Neuroscience. 2015 Nov 19;309:51-67. doi: 10.1016/j.neuroscience.2015.03.006. PMID:25772787 PMCID: PMC4567973

    Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Lam LC, Wong CH, Fung AW, Guaita A, Vaccaro R, Davin A, Ganguli M, Dodge H1, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration. PLoS One. 2015 Nov 5;10(11):e0142388. doi: 10.1371/journal.pone.0142388. PMID:26539987 PMCID:PMC4634954

    Friedman EM, Shih RA, Langa KM, Hurd MD.US prevalence and predictors of informal caregiving for dementia. Health Aff (Millwood). 2015 Oct;34(10):1637-41. doi: 10.1377/hlthaff.2015.0510. PMID: 26438738 PMCID:PMC4872631

    Beach PA, Huck JT, Miranda MM, Bozoki AC. Autonomic, behavioral, and subjective pain responses in Alzheimer’s disease. Pain Med. 2015 Oct;16(10):1930-42. doi: 10.1111/pme.12769. PMID: 25929320

    Beach PA, Huck JT, Miranda MM, Bozoki AC. Factors associated with cognitive evaluations in the United States. Pain Med. 2015 Oct;16(10):1930-42. doi: 10.1111/pme.12769. PMID: 25929320

    Lichtenberg PA, Ficker LJ, Rahman-Filipiak A. Financial decision-making abilities and exploitation in older African Americans: Preliminary validity evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS). J Elder Abuse Negl. 2016;28(1):14-33. doi: 10.1080/08946566.2015.1078760. PMID:26285038 PMCID:PMC4740256

    Oh SY, He F, Krans A, Frazer M, Taylor JP, Paulson HL, Todd PK. RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Hum Mol Genet. 2015 Aug 1;24(15):4317-26. doi: 10.1093/hmg/ddv165. PMID: 25954027 PMCID: PMC4492395

    Votruba KL, Persad C, Giordani B. Patient mood and instrumental activities of daily living in Alzheimer disease: Relationship between patient and caregiver reports. J Geriatr Psychiatry Neurol. 2015 Sep;28(3):203-9. doi: 10.1177/0891988715588829. PMID: 26071443

    Levine DA, Galecki AT, Langa K3, Unverzagt FW, Kabeto MU, Giordani B, Wadley VG. Trajectory of cognitive decline after incident stroke. JAMA. 2015 Jul 7;314(1):41-51. doi: 10.1001/jama.2015.6968. PMID:26151265 PMCID:PMC4655087

    Kotagal V, Bohnen NI, Müller ML, Koeppe RA, Frey KA, Langa KM, Albin RL. Educational attainment and motor burden in Parkinson’s disease. Mov Disord. 2015 Jul;30(8):1143-7. doi: 10.1002/mds.26272. PMID:26096339 PMCID:PMC4504749

    Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7821-6. doi: 10.1073/pnas.1509744112. PMID:26056265 PMCID:PMC4485101

    Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium; GERAD1 Consortium; EPIC-InterAct Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Associations between potentially modifiable risk factors and Alzheimer disease: A Mendelian Randomization Study. PLoS Med. 2015 Jun 16;12(6):e1001841; discussion e1001841. doi: 10.1371/journal.pmed.1001841. PMID:26079503 PMCID:PMC4469461

    Fyock CA, Hampstead BM. Comparing the relationship between subjective memory complaints, objective memory performance, and medial temporal lobe volumes in patients with mild cognitive impairment. Alzheimers Dement (Amst). 2015 Jun 1;1(2):242-248. PMID: 26191540 PMCID:PMC4501028

    Monsell SE, Dodge HH, Zhou XH, Bu Y, Besser LM, Mock C, Hawes SE, Kukull WA, Weintraub S; Neuropsychology Work Group Advisory to the Clinical Task Force. Results from the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study. Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):134-9. doi: 10.1097/WAD.0000000000000111. PMID:26485498 PMCID:PMC4834278

    Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci. 2015 Apr 15;35(15):6165-78. doi: 10.1523/JNEUROSCI.3013-14.2015. PMID:25878288 PMCID:PMC4397610

    Langa KM. Is the risk of Alzheimer’s disease and dementia declining? Alzheimers Res Ther. 2015 Mar 26;7(1):34. doi: 10.1186/s13195-015-0118-1. PMID: 25815064 PMCID:PMC4374373

    Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA.A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. 2016 Jan;21(1):108-17. doi: 10.1038/mp.2015.23. PMID: 25778476 PMCID: PMC4573764

    Moon SW, Dinov ID, Kim J, Zamanyan A, Hobel S, Thompson PM, Toga AW. Structural neuroimaging genetics interactions in Alzheimer’s Disease. J Alzheimers Dis. 2015;48(4):1051-63. doi: 10.3233/JAD-150335. PMID:26444770 PMCID:PMC4730943

    Beck JS, Mufson EJ, Counts SE. Evidence for mitochondrial UPR gene activation in familial and sporadic Alzheimer’s disease. Curr Alzheimer Res. 2016;13(6):610-4. PMID:26687188

    Moon SW, Dinov ID, Zamanyan A, Shi R, Genco A, Hobel S, Thompson PM, Toga AW; Alzheimer's Disease Neuroimaging Initiative (ADNI). Gene interactions and structural brain change in early-onset Alzheimer’s disease subjects using the pipeline environment. Psychiatry Investig. 2015 Jan;12(1):125-35. doi: 10.4306/pi.2015.12.1.125. PMID:25670955 PMCID:PMC4310910

    Hampstead BM, Khoshnoodi M, Yan W, Deshpande G, Sathian K.Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults. Neuroimage. 2016 Jan 1;124(Pt A):997-1008. doi: 10.1016/j.neuroimage.2015.10.002. PMID:26458520

    Paulson D, Lichtenberg PA. The Paulson-Lichtenberg Frailty Index: evidence for a self-report measure of frailty. Aging Ment Health. 2015;19(10):892-901. doi: 10.1080/13607863.2014.986645. PMID:25537004 PMCID:PMC4480217

     

  • Archived Studies

    Improving Alertness During Long Drives: A Driving Simulation Study

    Principal Investigator (PI): Bruno Giordani, PhD
    Co-PI: Carol Persad, PhD

    Project Description This study involves the use of a computerized driving simulator to find out if engaging in simple game-like tasks could promote alertness and improved driving performance in fatigued drivers. The study will take place in 2 separate sessions that will last approximately 2 hours each. Participants will be compensated for their time spent in the study.

    Participation Criteria:  Persons aged 55-65 years with a valid driver’s license over the past 2 years and driving in past 6 months.

    NOBLE

    Principle Investigator (PI): Judith Heidebrink MD, MS

    Project Description: The purpose of this research study is to determine whether an investigational drug, T-817MA (also called “T-817”), is safe and beneficial in delaying or altering the decline in memory and daily functioning when given to people with Alzheimer’s disease (AD). We will also be studying the effect of T-817 on brain magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers. The U.S. Food and Drug Administration (FDA) has not approved T-817 for the treatment of AD and we do not know whether daily use of T-817 can change the course of the disease.

    Participant Criteria: Male or female 55-85 years old; have AD and are experiencing memory problems; currently taking a medication (donepezil [Aricept®] or rivastigmine transdermal system (Exelon® Patch)  or donepezil or Rivastigmine and memantine [Namenda™]) for the treatment of AD; have brain MRI or CT result consistent with Alzheimer’s disease; residing in the community with a designated study partner who will accompany the patient to all clinic visits and participate in the evaluations (see protocol details). You may NOT qualify for participation in this study if you use any drug other than donepezil or Exelon Patch (with or without memantine) for Alzheimer’s disease, including galantamine (razadyne); have other neurodegenerative diseases, including Parkinson’s disease, Huntington’s disease, or cerebral tumor; have history of untreated thyroid disorder, Type I diabetes, and insulin-dependent, or uncontrolled Type II diabetes, as determined by the PI (except non-insulin controlled Type II diabetes, whose HbA1c value must be below 8.0 %).

    Contact: Kathryn Steen MA, kesteen@med.umich.edu 734-736-9909

    Retaining Identity: Creativity and Caregiving

    Principle Investigator (PI): Anne Mondro, MFA, Elaine Reed, BFA

    Project Description The goal of our study is to better understand the role of art in the support network of adults with memory loss and their care partners.  In the first four weeks, caregivers will learn how to use art materials, explore their creativity, develop a basic understanding of art and design principles, and build communication skills for working with persons with memory loss through art making and guided discussions.  Respite care will be available.  In the following four weeks, the caregiver will teach the same projects to their care recipient.  Facilitators will help guide the caregiver in how to structure the projects for their partner and aid in providing ways to communicate successfully in leading their partner through the art making.  A guided discussion with the group will follow.  All sessions will be held at the Turner Senior Resource Center in Ann Arbor.  Free, close to the building parking is available.  Materials and supplies are free to all participants.

    Participation Criteria: Diagnosis of mild to moderate Alzheimer’s disease; 50 years of age or over; fluent in English; a study partner/caregiver is required.

    ContactAnnie Hyrila, hyrilann@umich.edu , 734-763-3534
    Retaining Identity:  Creativity and Caregiving brochure (PDF)

    The WeCareAdvisor Tool to Assist Families Living with Dementia

    Principal Investigator (PI): Helen Kales, MD

    Project Description Our study is currently seeking family caregivers to test the WeCareAdvisor, a customized, easy-to-use, internet-based tool that aims to assist in better understanding and managing behavioral symptoms that are a part of dementia.  Participants will be interviewed by telephone and then in their home.  If it is determined that the study is right for the caregiver and their family member with dementia, they will be randomly assigned to one of two groups that will test the WeCareAdvsior tool for a one-month period.  Group A will receive the WeCareAdvisor and begin their trial testing immediately.  Group B will test the WeCareAdvisor after a one-month waiting period.  During the one month testing period of the WeCareAdvisor participants will also receive weekly check-in phone calls from a research team member.  Participants will be compensated for their time spent in the study.

    Participation Criteria:  The in-home primary caregiver for a person living with dementia, 21 years of age or older, managing behaviors the caregiver finds challenging and comfortable with technology.

    Contact:  Molly Turnwald, turnwald@umich.edu, 734-232-0393

    FYN

    Principal Investigator (PI):  Judith Heidebrink MD, MS

    Project DescriptionThe purpose of this research study is to determine whether AZD0530 is safe and effective in slowing decline in brain metabolism, memory and daily function in people with Alzheimer’s disease. Researchers believe that AZD0530 works by protecting your brain cells from the damage caused by amyloid protein. Amyloid protein is known to be associated with the development of AD. We will use imaging tests to see if AZD0530 affects brain structure and function, and also look at certain proteins in the blood and spinal fluid (the fluid surrounding the brain and spinal cord) that are associated with Alzheimer’s disease.

    Participant Criteria:  You must be male or female between the ages of 55-85 and have a diagnosis of Alzheimer’s disease.  You must be in good general health and be on stable medications.  You must have a study partner who is willing to accompany you to your study visits and monitors your study medication and how you are doing on a day to day basis.

    Merck 19

    Principle Investigator (PI):  Judith Heidebrink MD, MS

    Project Description: The purpose of the study is to test the safety and efficacy of MK-8931 in the treatment of individuals with amnestic Mild Cognitive Impairment due to Alzheimer’s disease (AD). The study will assess the effects that two doses of MK-8931 have on disease progression.

    Participation Criteria:  Male or female between the ages of 55 and 85; Mild Cognitive Impairment due to Alzheimer’s Disease; a spouse, friend, relative, or caregiver who is willing to accompany them to all of the study visits, monitor them while they are taking the study drug and communicate changes in the patient’s health status over the period of this study.

    Contact: Kathryn Steen MA, kesteen@med.umich.edu 734-736-9909

    BAN2401

    Principal Investigator (PI):  Nancy Barbas MD, MSW

    Project Description The purpose of the BAN2401 research study is to find out if BAN2401 has a positive effect on a person’s cognitive ability based on a series of specialized cognitive tests. The purpose of this research is also to find out if the study drug is safe and well-tolerated in people with early Alzheimer’s disease. People with Alzheimer’s disease have a build-up of abnormal protein known as amyloid in their brains. BAN2401 is thought to reduce the amount of this abnormal protein.  The study drug will be given by injecting it into a vein. Analysis will be performed to find out how much of the study drug is in the blood at different times after the injection.

    Participation Criteria: Diagnosis of Mild Cognitive Impairment (MCI) or mild Alzheimer’s disease, male or female between the ages of 50 and 90, and ability to provide written consent

    Contact: Amanda Rasnake BSN, RN, CCRP, arasnake@med.umich.edu 734-232-2452