Research

The Michigan Alzheimer’s Disease Center (MADC) conducts and supports innovative memory and aging research that seeks to:

Researcher from Henry L. Paulson's llab looking at a computer image of plaques on the brain of a mouse.

Henry L. Paulson’s Lab

  • identify disease modifying treatments
  • understand disease mechanisms in AD and other dementias
  • define biomarkers for early and accurate detection
  • devise effective coping strategies for individuals with memory loss and their care-partners

Despite tremendous recent advances in understanding Alzheimer’s disease and related dementias, there’s still much we do not know about the causes of dementing disorders and how to slow down or prevent them altogether.  Clinicians and scientists alike need to take a broad, fresh view of the causes of dementia and the potential routes to better therapy.  The MADC is deeply committed to this task. Building from the rich expertise present across the University campus, the MADC strives to foster cutting-edge research toward a better understanding and better treatment of Alzheimer’s disease, Lewy Body Disease, frontotemporal dementia and other related disorders. 

Areas of research emphasis include investigations of the quality control machinery that counters aggregated proteins in dementia, imaging studies that seek to improve our ability to diagnose disease earlier and more accurately, and explorations of the interplay between metabolic disorders (e.g. obesity, diabetes) and Alzheimer’s disease.  A key part of the MADC mission is to make connections – linking scientists to scientists, clinicians to scientists, volunteers to studies, even programs to programs.  Through these connections, we can lower the barriers to solving the challenging problems associated with dementia.

If you are interested in learning more about how to participate in an MADC-support study, please visit our Join a Study page.