August 22, 2016

For Professionals

  • Need Help with Recruitment?

    The MADC promotes clinical research on memory and aging that involves direct use of research volunteers, biomarkers, and other clinical data collected through the University of Michigan Memory and Aging Project (UM-MAP).  The MADC manages a well-characterized dataset to facilitate recruitment for MADC-supported projects and publications.

    Clinical Resource Application

    Investigators wishing to utilize the research volunteer database must complete the MADC Clinical Resource Application (PDF).

    Data Requests

    Do we have the resources you are looking for?  For preliminary data requests, please complete and submit the MADC Data Request Form.

    For more information, contact Arijit Bhaumik, 734-936-8281 or arijit@med.umich.edu.

    Continuing Education Resources

    University of Michigan School of Social Work – Web-Based Certificate in Advanced Clinical Dementia Practice

    Acknowledgement and Logos

    Please remember to acknowledge partial support from NIH/NIA grant 5P30AG053760 in your publications, presentations, web-sites, posters, and other dissemination efforts that are related to MADC research, development and training activities and also include an approved MADC logo.

    Text must read:

    This <project/study (choose one)> was partially supported by the NIH/NIA funded Michigan Alzheimer’s Disease Center (5P30AG053760).

    Logos:

    For approved MADC logos to use in posters and presentations, please contact:

    Arijit Bhaumik – arijit@med.umich.edu 

    Nancy Laracey – laracey@med.umich.edu

    Renee Gadwa – rgadwa@med.umich.edu

  • The MADC Pilot Project Program

    As we seek to understand and cure AD and related dementias, the MADC considers it among our highest priorities to support innovative, high impact research. The MADC Pilot Project Program provides “kick-starter” funds to U-M investigators so that they can begin testing new ideas about the causes and treatment of dementias. The MADC is committed to funding $35,000 pilot projects per year, open to any investigators at UM, MSU, WSU and Ann Arbor VA.

    2018-2019 Funded Pilot Projects

    "Characterization of faster onset of Alzheimer’s disease within mild cognitive impairment patients by brain functional connectivity and genetic variants"

    Eunjee Lee, PhD (University of Michigan) and Chandra Sripada, PhD (University of Michigan)

    Goal: To uncover multi-model brain functional connectivity/gene markers of shorter conversion time from MCI to AD by constructing advanced Bayesian low rank models.

    Dr. Eunjee Lee is a Research Assistant Professor of Biostatistics at the University of Michigan. Her research interests lie in developing statistical methods to explore biomedical data, such as brain imaging and genetic data. Her current work is focused on Bayesian methods for functional data analysis, matrix decomposition, and variable selection in high-dimensional settings.

    Dr. Chandra Sripada is an Associate Professor of Psychiatry and an Associate Professor of Philosophy at the University of Michigan. His research examines agency, attention, and self-control from cross-disciplinary perspectives.

    "Cortical Microstructural Changes in African-Americans with Alzheimer’s Disease"

    Navid Seraji-Bozorgzad, MD (University of Michigan) and Rohit Marawar, MD (Wayne State University)

    Goal: To examine the cortical microstructure as reflected by two novel MRI techniques, Neurite Orientation Dispersion and Density Imaging (NODDI) and Diffusion Kurtosis Imaging (DKI) in a cohort of African American and White patients with early Alzheimer’s disease.

    Dr. Seraji-Bozorgzad is an Assistant Professor of Neurology at the University of Michigan. The interaction of body and brain in disease state are of particular interest to him, both in terms of neurological manifestations of systemic disease, and effect of neurological disease on other systems. His research experience is in the field of MR imaging. He is interested in biomarkers of brain injury and repair, as it applies to various degenerative disorders, including Alzheimer’s disease.

    Dr. Rohit Marawar is an Assistant Professor of Neurology at Wayne State University. Dr. Marawar’s expertise and training is in the field of epilepsy. Recently, he transitioned his focus into hyperexcitable brain networks in cognitively normal and abnormal elderly – including those with Alzheimer’s disease and related dementias. Dr. Marawar contributed to the development of the Geriatric Epilepsy Clinic at Wayne State University-Detroit Medical Center.

    “RNA binding protein sequestration in Non-Amyloid Dementia”

    Peter Todd, MD, PhD (University of Michigan)

    Goal: To leverage emerging technologies to identify novel repeat associated RNA-binding proteins (RBPs) and then evaluate their roles in two common genetic forms of dementia: C9orf72-associated frontotemporal dementia (C9FTD) and fragile X-associated tremor/ataxia syndrome (FXTAS).

    Dr. Peter Todd is the Bucky and Patti Harris Career Development Professor of Neurology and an Associate Professor of Neurology at the University of Michigan. His research explores the molecular mechanisms in neurodegenerative diseases with a particular interest in repeat expansion diseases such as the recently discovered C9ORF72 expansion underlying frontotemporal dementia. Dr. Todd is also a staff neurologist at the Ann Arbor VA Medical Center. He has worked in the field of Fragile X research for almost 20 years.

    “Inflammation, social stress, and racial disparities in cognitive aging”

    Laura Zahodne, PhD (University of Michigan)

    Goal: To test the overarching hypothesis that racially-patterned social stress (discrimination) partially explains disparities in cognitive health through its effects on inflammation. In addition, this study will test whether associations among race, social stress, inflammation, and cognition differ according to socioeconomic status and quantify effects of examiner-examinee racial discordance on cognitive performance.

    Dr. Laura Zahodne is a clinical neuropsychologist and an Assistant Professor of Psychology at the University of Michigan. Her research interests include psychosocial factors in aging and neurodegenerative disease, psychosocial factors and racial/ethnic diversity in cognitive aging, and statistical modeling of symptom trajectories in aging and neurodegenerative disease.

    2017-2018 Funded Pilot Projects

    "Hippocampal Connectivity Along The Spectrum of Pre-clinical Alzheimer’s Disease"

    Jessica Damoiseaux, PhD

    Assistant in the Institute of Gerontology and the Department of Psychology at Wayne State University

    Goal: To determine the difference in hippocampal functional and structural connectivity among older adults along the putative preclinical spectrum from healthy to subjective cognitive impairment (SCI) and mild cognitive impairment (MCI), and its association with objective cognitive performance.

    Outcome: Project is ongoing.

    "Determine The Role of the Novel EFhd2 Protein on Tau Oligomerization"

     

    Irving Vega, PhD

    Associate Professor of Translational Science & Molecular Medicine at Michigan State University

     

     

    Magdalena Ivanova, PhD

    Research Assistant Professor of Neurology and Adjunct Assistant Professor of Biophysics at the University of Michigan

    Goal: To understand the role of EFhd2 as a putative modulator of tau oligomerization, in a collaborative effort between researchers at Michigan State University and University of Michigan.

    Outcome: Project is ongoing.

     

    "Leveraging Longitudinal Electronic Health Records for the Characterization of the Progression of Alzheimer's Disease"

    Jenna Wiens, PhD

    Assistant Professor in Computer Science Engineering (CSE) at the University of Michigan

    Goal: The development of methods for leveraging University of Michigan Health System and VA Health Administration Electronic Health Record data for novel retrospective analyses of patient trajectories prior to and following a diagnosis with MCI and AD.

    Outcome: Project is ongoing.

    "Defining RNA-based Mechanisms of Neurodegeneration in FTLD-TDP"

    Sami Barmada, MD, PhD

    Associate Professor of Neurology at the University of Michigan

    Goal: To determine the importance of TDP43’s RNA binding domains to neurotoxicity, and to define the TDP43 targets that most closely associate with neurodegeneration in frontotemporal dementia models.

    Outcome: Project is ongoing.

    This project is funded by the Erb Family Foundation Grant

    2015 Funded Pilot Projects

    “Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive Impairment (MCI)”

    Deborah A. Levine, MD, MPH
    Assistant Professor of Internal Medicine and Assistant Professor of Neurology

    levinedeborahmdsm

    Goal: to develop, test, and disseminate strategies to improve the care and clinical decision-making of older patients with MCI

    Outcome: Data from this study was incorporated into an R01 grant application with Dr. Levine as PI which was funded. They are still in the data collection and analysis phase. There are no publications at this time.

    “Screening for novel G4C2 hexanucleotide repeat expansions in neurodegenerative disease”

    Peter K Todd, MD, PhD
    Harris Career Development Professor of Neurology
    Peter Todd
    Goal: To identify novel hexanucleotide repeat expansions as a first step in establishing their roles in the biology of dementia

    Outcome: They did not identify any novel repeat expansions as a cause of ALS or other disorders.

    Publications: He F, Jones JM, Figueroa-Romero C, Zhang D, Feldman EL, Goutman SA, Meisler MH, Callaghan BC, Todd PK. Screening for novel hexanucleotide repeat expansions at ALS- and FTD-associated loci. Neurology Genetics. Volume 2, Issue 3, May 11th 2016, Page 71.

    “Novel approaches to measuring and facilitating the clearance of soluble amyloid from the brain”

    Vikas Kotagal, MD, MS
    Assistant Professor of Neurology

    Goal: To test the primary hypothesis that scalp cooling facilitates the glymphatic system and enhances clearance of soluble A-beta.

    Outcome: Project is currently ongoing. Dr. Kotagal acquired a mentored VA grant this year.

    Publications: There are no publications at this time.

    “Reducing subjective memory complaints in older adults through non-invasive brain stimulation”

    Benjamin Hampstead, PhD
    Associate Professor of Psychiatry, Neuropsychology Section
    bhampste-1

    Goal: To examine whether tDCS can reduce the severity of SMCs and improve memory test performance in older adults with such complaints.

    Outcome: Project is ongoing.

  • brain-bank-long


    The Michigan Brain Bank is designed to support investigations of dementing disorders.  The Brain Bank provides researchers who study AD and related disorders with access to well-characterized human brain tissue. To optimize research, the Brain Bank assists in the collection and storage of brain tissue from individuals who have been followed in research studies at the University of Michigan and other centers. We are fortunate to have had many generous patients and families participate in this brain donation program. The most useful tissue for research comes from individuals with extensive clinical information, typically from those who have participated in clinical research projects. Tissues stored in the MADC Brain Bank are extensively characterized by experienced pathologists and available to scientists on request.  Brain Bank tissues have been used by numerous scientists here and at other centers in the USA.

    For investigators wishing to utilize tissues stored in the Michigan Brain Bank, please visit the Michigan Brain Bank website to download and submit tissue resource applications.  Investigators may also download the Tissue Resource Application and submit it via mail.

    For further information, please contact Matthew Perkins at UMHSbrainbank@med.umich.edu or 734-647-7648.

  • Michigan Alzheimer Disease Core Center Junior Investigator Mentoring Program

    The Michigan Alzheimer’s Disease Core Center (MADCC) offers the MADCC Mentoring Program for Junior Investigators (MMPJI).  The MMPJI has 2 aims.  One, providing junior investigators entering the field of dementia research with a broad education about contemporary dementia research. Two, providing junior investigators with mentoring by experienced investigators in developing competitive grant applications. The MMPJI is a 2 year program with the following components:

    • An online curriculum about contemporary dementia research to introduce mentees to basic features of dementias.
    • An individually tailored mentoring committee of experienced investigators to assist mentees with preparation of competitive grant applications.
    • Participation in the Career Development Workshop jointly sponsored by the MADCC and the University of Michigan Pepper Center.  This workshop takes place in the spring and includes a Mock Study Section and other career development activities.
    • Mentees receive preferred (not guaranteed) access to MADCC Core resources and Pilot Grant programs.

     

    Eligibility Criteria Include:

    • Career commitment to some form of dementia-related research.  This covers the whole spectrum of research from social science work to basic biology.
    • Post-doctoral fellow or junior faculty status.
    • Realistic plans to submit a grant application within the next 2 years.

     

    We are not currently accepting applications for this program. Please check back here to see when openings are available.