The Michigan Alzheimer’s Disease Center conducts and supports innovative memory and aging research that seeks to:
- identify disease modifying treatments
- understand disease mechanisms in AD and other dementias
- define biomarkers for early and accurate detection
- devise effective coping strategies for individuals with memory loss and their care-partners
Despite tremendous recent advances in understanding Alzheimer’s disease and related dementias, there’s still much we do not know about the causes of dementing disorders and how to slow down or prevent them altogether. Clinicians and scientists alike need to take a broad, fresh view of the causes of dementia and the potential routes to better therapy. The MADC is deeply committed to this task. Building from the rich expertise present across the University campus, the MADC strives to foster cutting-edge research toward a better understanding and better treatment of Alzheimer’s disease, Lewy Body Disease, frontotemporal dementia and other related disorders.
Areas of research emphasis include investigations of the quality control machinery that counters aggregated proteins in dementia, imaging studies that seek to improve our ability to diagnose disease earlier and more accurately, and explorations of the interplay between metabolic disorders (e.g. obesity, diabetes) and Alzheimer’s disease. A key part of the MADC mission is to make connections – linking scientists to scientists, clinicians to scientists, volunteers to studies, even programs to programs. Through these connections, we can lower the barriers to solving the challenging problems associated with dementia.
Drug Treatment StudiesPRESENCE
Evaluating the safety and efficacy of LY3154207 (positive allosteric modulator of the D1 receptor) on cognition in patients with mild-moderate Parkinson’s disease dementia. Study is looking for adults with Parkinson’s disease and dementia age 40-85, with well-controlled blood pressure and a reliable caregiver who is able to be present for certain visits. Contact Braden DeWeese at email@example.com or 734-615-5495 for more information.
Memory Training StudiesPromoting adaptive neuroplasticity in mild cognitive impairment (Merit)
Examining the benefits of two types of treatments for memory impairment – cognitive rehabilitation and electrical brain stimulation. Study is looking for adults with mild cognitive impairment over the age of 50. Contact Julia Laing at firstname.lastname@example.org or 734-764-4709.
Neuroimaging and Biomarker StudiesExamination of the earliest symptoms and biomarkers of FTLD MAPT carriers
Investigating the earliest clinical features of frontotemporal dementia in an effort to improve early detection of the disease. Study is looking for adults age 18 and older with a family member who has frontotemporal dementia. Contact Stephen Campbell at email@example.com or 734-763-2361.Lewy Body Dementia Biomarkers
Investigating new brain imaging approaches that investigators hope will identify protein accumulations in the brain of individual patients with PD-related dementia. This study is looking for adults age 55 and older with Parkinson’s disease dementia (PDD), Dementia with Lewy Bodies (DLB), or Alzheimer’s disease with at least one symptom of DLB. Contact Christine Minderovic at firstname.lastname@example.org or 734-998-8420.Risk Evaluation and Education of Alzheimer’s Disease – the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)
The purpose of this study is to learn about the best ways to communicate educational information about amyloid imaging brain scans and risk information about the chance of developing AD. Study is enrolling cognitively normal adults ages 65 to 80, have/had at least one first-degree relative (i.e., parent or siblings) with Alzheimer’s disease. Contact Lan Le at email@example.com or 734-615-2422. This study team sees participants in Ann Arbor and Detroit.
Lifestyle Intervention StudiesUniversity of Michigan Memory and Aging Project (UM-MAP)
Investigating changes in cognitive functioning over time to learn more about normal aging and neurodegenerative diseases. Study is looking for adults with or without cognitive changes over the age of 55. Contact Holly Bunker at firstname.lastname@example.org or 734-615-5319. This study team sees participants in Ann Arbor and Detroit.Adaptive Coping Engagement with Caregivers of Black Older Adults with Dementia (ACE Project)
The ACE Project is investigating caregiver mental health, physical health, and social supports with the aim of developing culturally tailored programming. This study is seeking African American/ Black caregivers of persons with dementia or cognitive impairments to complete a survey. Contact Dr. Sheria Robinson-Lane at email@example.com or 734-764-9280. This study team will meet participants in the home.Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI 3)
The purpose of this observational study is to determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of AD as it progresses from a preclinical stage to very mild symptoms to mild cognitive impairment (MCI) to dementia. Study is looking for adults age 55-90 with normal cognition, MCI, or mild AD. Contact Lisa Zbizek-Nulph at firstname.lastname@example.org or 734-232-1199.
Alzheimer's Prevention Trials (APT) Webstudy
The APT Webstudy is an online memory and thinking research tool aimed at accelerating enrollment into Alzheimer’s clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer’s. The study is looking for adults over age 50. Contact the study team at email@example.com or 1-858-877-3135, or visit https://www.aptwebstudy.org/welcome for more information about the study. This is a web-based study; a computer or mobile device with internet is necessary to participate.Developing a Personalized System to Assist Aging Drivers
The goal of this study is to understand driving behavior and factors that might influence how older adults drive. Being able to drive safely allows older adults to do many life-long activities that are important to them. Despite the importance of this topic, there has been little research studying factors that impact older adults in different driving scenarios. This study is designed to collect information on older adults’ driving over multiple days and on factors, such as physiological responses, that might influence their safe driving. This information will provide an important knowledge base for the future development of personalized systems to promote safe driving for older adults.
Eligible participants will be asked to complete appointments at the University of Michigan Neuropsychology Clinic (UM Neuropsychology) and the University of Michigan Transportation Research Institute (UMTRI). First, you will be asked to complete one appointment at UM Neuropsychology where you will use a computer-based driving simulator and complete a brief computer-based assessment of thinking and problem solving. This appointment will take up to 2 hours. Next, you will be asked to drive your own vehicle for five separate days while we collect on-road driving data. To do this we will ask you to visit UMTRI each morning and evening. During the first visit to UMTRI, we will install an in-vehicle data collection device and a small camera system in your vehicle. You will then be asked to drive as you normally would that day, returning to UMTRI in the evening to allow study staff to turn the data collection devices off. On each of the remaining four driving days you will return to UMTRI in the morning to turn on the data collection devices and return in the evening to turn them off. You will be asked to complete a survey while the devices are being installed in your vehicle, a brief survey when you return to UMTRI each evening, and a short interview while the devices are being removed from your vehicle at the end of the fifth driving day. The first UMTRI appointment will take up to 2 hours and the remaining UMTRI appointments will take approximately 15 minutes. Finally, for the simulator appointment and on-road driving, you will be asked to wear a chest belt and a special set of gloves that will measure physiological data like heart rate. Participants will be paid a total of $250 – distributed across the study visits.
Participation criteria: Age 65 or older; have a valid driver’s license; have been actively driving for at least one year; drive at least three times per week; drive a car that is model year 1996 or newer; are able to visit UMTRI two times per day during the five days of on-road driving data collection in your own vehicle over a two-week period.
Contact: Courtney Goetz, 734-764-6169, email: firstname.lastname@example.orgEnhancing Safe Mobility among Older Drivers
Investigating how older drivers might change their driving behavior over time and what influences any changes that might occur. Study is looking for both healthy adults and those with MCI age 65 or older. Contact Jennifer Zakrajsek at email@example.com or 734-615-4740.Internet-Based Conversational Engagement Clinical Trial (I-CONECT)
Investigating potential benefits of social engagement in healthy older adults, using regular phone or video chat conversations to improve health and well-being. Study is looking for healthy adults over the age of 80 who live alone in the Detroit metropolitan area. Contact the study team at I-CONECT_UM@ohsu.edu or 734-647-2676. This study involves phone and video chat visits in the home.
Mind ‘n MOTION
Investigating the use of Mindfulness-Based Stress Reduction and multifactorial balance control training as a method for reducing fall risk. Study is looking for adults with mild cognitive impairment age 55 and older. Contact Laura Rice-Oeschger at firstname.lastname@example.org or 734-936-8332.STYLE Study: Characterizing Dementia Caregiving Styles
This study is investigating how caregivers manage care and the impact of that care on the caregivers’ mental and physiological health, as well as health services use. The study is looking for primary caregivers of family members or friends with a diagnosis of dementia to participate. Contact Brianna Broderick at email@example.com or 734-232-0397.Subjective Cognitive Impairment – A Sign of Incipient Alzheimer’s Disease?
Longitudinal study investigating functional and structural brain changes in healthy older adults with and without cognitive complaints. Study is looking for adults age 60 or older with worrisome memory complaints or a diagnosis of mild cognitive impairment (MCI). Contact the Wayne State University Connect Lab at firstname.lastname@example.org or 313-664-2670. This study team is recruiting for visits at Wayne State University in Detroit.
Tele-Savvy: An Online Psychoeducation Program for Dementia Family Caregivers
The purpose of this study is to test the psychoeducational program "Tele-Savvy,” which is an internet-based group education program developed from an in-person program called Savvy Caregiver. Study is looking for informal caregivers (family/friends) of persons living with Alzheimer’s disease or another dementia over the age of 18. Contact Natasha Spoden at email@example.com or 503-494-6370. This study occurs via phone and computer (computer or mobile device with internet is necessary).
For a full printable list of our studies, click here.
Join a Study
Now is the time to join our research team. Research participation is a generous gift – a gift that can be shared with future generations as we pave the way to new discoveries in treatment and prevention.
Research participation contributes to the discovery of new ways to diagnose, treat and support people with Alzheimer’s disease or a related disorder. The University of Michigan Memory and Aging Project (UM-MAP), our primary memory and aging study at the MADC, aims to enhance our understanding of the earliest signs of memory or thinking changes. This study simply evaluates naturally occurring changes in behavior and health status of research volunteers over a period of time. Once you are enrolled in UM-MAP, our study coordinator can connect you to other observational, imaging and clinical drug trials that best fit your interests and needs.
We are currently seeking research volunteers experiencing early signs of memory changes as well as healthy older adults. We understand that participating in research is not always an easy decision. Individuals and their families should carefully consider all of the possible benefits and risks before agreeing to participate.
If you are interested in participating in research, please complete a Research Volunteer Form and mail or email to firstname.lastname@example.org.
Please contact Stephen Campbell at 734-763-2361 with any questions or concerns.
There are over 13 million Americans living with a brain disease or disorder. To find treatments and cures, researchers must study the human brain. The Michigan Brain Bank provides individuals and families an opportunity to contribute to this research effort.
Donated brains are collected and stored by the Michigan Brain Bank to help scientists around the world advance the understanding of brain disease and disorders. You can make a difference and help future generations by generously donating your brain to the Michigan Brain Bank.
If you are interested in donating to the Michigan Brain Bank or would like more information, please call 734-647-7648 or visit the Michigan Brain Bank website.
Brenowitz WD, Han F, Kukull WA, Nelson PT. Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging. 2018 Feb;62:64-71. doi: 10.1016/j.neurobiolaging.2017.10.004 PMID: 29107848 PMCID: PMC5743774
Cheran G, Silverman H, Manoochehri M, Goldman J, Lee S, Wu L, Cines S, Fallon E, Kelly BD, Olszewska DA, Heidebrink J, Shair S, Campbell S, Paulson H, Lynch T, Cosentino S, Huey ED. Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers. J Neurol Neurosurg Psychiatry. 2018 Jan 20:jnnp-2017. doi: 10.1136/jnnp-2017-317263 PMID: 29353234
Christensen KD, Uhlmann WR, Roberts JS, et al. A randomized controlled trial of disclosing genetic risk information for Alzheimer’s disease via telephone. Genetics in Medicine. 2018. 20(1), 132-41. doi: 10.1038/gim.2017.103. PMID: 28726810 PMCID: PMC5897910
Green KM, Glineburg MR, Kearse MG, Flores BN, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada SJ, Todd PK. RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nat Commun. 2017 Dec 8;8(1):2005. doi: 10.1038/s41467-017-02200-0 PMID: 29222490 PMCID: PMC5722904
Kotagal V, Spino C, Bohnen NI, Koeppe R, Albin RL. Serotonin, β-amyloid, and cognition in Parkinson disease. Ann Neurol. 2018 Apr 17. doi: 10.1002/ana.25236 PMID: 29665066
Howanitz, J., Carney, K.O, Lichtenberg, P.A., Donlan, A., Sugarman, M & Malek, K. Neurocognitive Engagement Therapy: An Innovative Rehabilitation Approach for those with Cognitive Impairment. Topics in Geriatric Rehabilitation. (In press).
Lichtenberg PA, Ocepek-Welikson K, Ficker LJ, Gross E, Rahman-Filipiak A, Teresi JA. Conceptual and Empirical Approaches to Financial Decision-making by Older Adults: Results from a Financial Decision-making Rating Scale. Clinical gerontologist. 2018 January;41(1):42-65. doi: 10.1080/07317115.2017.1367748 PMID: 29077531 PMCID: PMC5766370
Park SK, Arslan F, Kanneganti V, Barmada SJ, Purushothaman P, Verma SC, Liebman SW. Overexpression of a conserved HSP40 chaperone reduces toxicity of several neurodegenerative disease proteins. Prion. 2018 Jan 31:1-7. doi: 10.1080/19336896.2017.1423185. PMID: 29308690 PMCID: PMC5871033
Silbert LC, Lahna D, Promjunyakul NO, Boespflug E, Ohya Y, Higashiuesato Y, Dodge HH (2018). Risk Factors Associated with Cortical Thickness and White Matter Hyperintensities in Dementia Free Okinawan Elderly. J Alzheimers Dis, 63(1), 365-372. doi:10.3233/JAD-171153 PMID: 29578488 PMCID: PMC5900560
Tarraf W, Criqui MH, Allison MA, Wright CB, Fornage M, Daviglus M, Kaplan RC, Davis S, Conceicao AS, González HM. Ankle brachial index and cognitive function among Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos. Atherosclerosis. 2018 Apr 1;271:61-9. doi: 10.1016/j.atherosclerosis.2018.02.016 PMID: 29459267
Tiernan CT, Mufson EJ, Kanaan NM, Counts SE. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. J Neuropathol Exp Neurol. 2018; 77(3):246-259. doi: 10.1093/jnen/nlx120. PMID: 29378005
Uhlmann WR, Roberts JS. Ethical issues in neurogenetics. In D Geschwind, C Klein, H Paulson (Eds.), Handbook of Clinical Neurology. 2018. 147, 23-36. Elsevier. doi: 10.1016/B978-0-444-63233-3.00003-8. PMID: 29325614 PMCID: PMC5896012
Wang B, Zeng L, Merillat SA, Fischer S, Ochaba J, Thompson LM, Barmada SJ, Scaglione KM, Paulson HL. The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin. Neurobiol Dis. 2018 Jan;109(Pt A):127-136. doi: 10.1016/j.nbd.2017.10.002. PMID: 28986324
Weden MM, Shih RA, Kabeto MU, Langa KM. Secular Trends in Dementia and Cognitive Impairment of U.S. Rural and Urban Older Adults. Am J Prev Med. 2018 Feb;54(2):164-172. doi: 10.1016/j.amepre.2017.10.021 PMID: 29246677 PMCID: PMC5783777
Weskamp K, Barmada SJ. TDP43 and RNA instability in amyotrophic lateral sclerosis. Brain Res. 2018 Jan 29. pii: S0006-8993(18)30023-4. doi: 10.1016/j.brainres.2018.01.015. PMID: 293950442017
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ. Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123 PMID: 29256861 PMCID: PMC5743427
Albin RL. Mitigating the burden of neurological disease. Annals of neurology. 2017 Aug;82(2):315. doi: 10.1002/ana.25001 PMID: 28752897 PMCID: PMC5870892.
Albin RL. Polyglutamine inclusion body toxicity. Movement disorders : official journal of the Movement Disorder Society. 2017 December;32(12):1686. doi: 10.1002/mds.27226 PMID: 29119663 PMCID: PMC5744902
Ankuda CK, Harris J, Ornstein K, Levine DA, Langa KM, Kelley AS. Caregiving for Older Adults with Obesity in the United States. J Am Geriatr Soc. 2017 Sep;65(9):1939-1945. doi: 10.1111/jgs.14918 PMID: 28449347 PMCID: PMC5603353
Ankuda CK, Maust DT, Kabeto MU, McCammon RJ, Langa KM, Levine DA. Association Between Spousal Caregiver Well-Being and Care Recipient Healthcare Expenditures. J Am Geriatr Soc. 2017 Oct;65(10):2220-2226. doi: 10.1111/jgs.15039 PMID: 28836269 PMCID: PMC5762126
Anstey KJ, Peters R, Clare L, Lautenschlager NT, Dodge HH, Barnes DE, Shahar S, Brodaty H, Rees G. Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP). International psychogeriatrics. 2017 November;29(11):1757-1760. PMID: 28899450 PMCID: PMC5873600.
Basal LA, Yan Y, Shen Y, Haacke EM, Mehrmohammadi M, Allen MJ.Oxidation-Responsive, EuII/III-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging. ACS Omega. 2017 Mar 31, 2(3): 800-805. doi: 10.1021/acsomega.6b00514. PMID: 28393130 PMCID: PMC5377279
Counts SE, Ikonomovic MD, Mercado N, Vega IE, Mufson EJ. Biomarkers for the Early Detection and Progression of Alzheimer's Disease. Neurotherapeutics. 2017 Jan,14(1): 35-53. doi: 10.1007/s13311-016-0481-z. PMID: 27738903 PMCID: PMC5233625
Crosson B, Hampstead BM, Krishnamurthy LC, Krishnamurthy V, McGregor KM, Nocera JR, Roberts S, Rodriguez AM, Tran SM. Advances in Neurocognitive Rehabilitation Research from 1992 to 2017: The Ascension of Neural Plasticity. Neuropsychology. 2017 Aug 31. doi: 10.1037/neu0000396 PMID: 28857600 PMCID: PMC5788715
Dodge HH, Zhu J, Hughes TF, Snitz BE, Chang CH, Jacobsen EP, Ganguli M. Cohort effects in verbal memory function and practice effects: a population-based study. International Psychogeriatrics. 2017 Jan, 29(1): 137-148. doi: 10.1017/S1041610216001551. PMID: 27725002 PMCID: PMC5177461
Dodge HH, Zhu J, Woltjer R, Nelson PT, Bennett DA, Cairns NJ, Fardo DW, Kaye JA, Erten-Lyons D, Mattek N, Schneider JA, Silbert LC, Xiong C, Yu L, Schmitt FA, Kryscio RJ, Abner EL. Risk of incident clinical diagnosis of AD-type dementia attributable to pathology confirmed vascular disease. Alzheimer's & Dementia. Alzheimer's and Dementia. 2017, 13(6): 613–623. doi: 10.1016/j.jalz.2016.11.003 PMID: 28017827 PMCID: PMC5466467
Davis MA, Guo C, Sol K, Langa KM, Nallamothu BK. Trends and Disparities in the Number of Self-reported Healthy Older Adults in the United States, 2000 to 2014. JAMA internal medicine. 2017 November 1;177(11):1683-1684. doi: 10.1001/jamainternmed.2017.4357 PMID: 28975206 PMCID: PMC5753793
Gardner RC, Langa KM, Yaffe K. Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study. PLoS Med. 2017 Mar 7, 14(3): e1002246. doi: 10.1371/journal.pmed.1002246. PMID: 28267747 PMCID: PMC5340352
Ginsberg SD, Malek-Ahmadi MH, Alldred MJ, Che S, Elarova I, Chen Y, Jeanneteau F, Kranz TM, Chao MV, Counts SE, Mufson EJ. Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease. Hippocampus. 2017 Sept 9. doi:10.1002/hipo.22802. doi: 10.1002/hipo.22802 PMID: 28888073 PMCID: PMC5844851
Grill JD, Apostolova LG, Bullain S, Burns JM, Cox CG, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez OL, Mapstone M, Pierce A, Rabinovici G, Roberts JS, Sajjadi SA, Teng E, Karlawish J.Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther. 2017 May 4;9(1):35. doi: 10.1186/s13195-017-0261-y PMID: 28472970 PMCID: PMC5418690
Guan Y, Roter DL, Wolff JL, Gitlin LN, Christensen KD, Roberts JS, Green RC, Erby LH. The impact of genetic counselors’ use of facilitative strategies on cognitive and emotional processing of genetic risk disclosure for Alzheimer’s disease. Patient education and counseling. 2017 Nov 27. doi: 10.1016/j.pec.2017.11.019 PMID: 29203084 PMCID: PMC5911203
Gupta R, Lan M, Mojsilovic-Petrovic J, Choi WH, Safren N, Barmada S, Lee MJ, Kalb R.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded <i>C9ORF72</i> Inhibits the Proteasome. eNeuro. 2017 Jan 31, 4(1). pii: ENEURO.0249-16.2017. doi: 10.1523/ENEURO.0249-16.2017. PMID: 28197542 PMCID: PMC5282547
Hampstead BM, Sathian K, Bikson M, Stringer AY. Combined Mnemonic Strategy Training and High-Definition Transcranial Direct Current Stimulation for Memory Deficits in Mild Cognitive Impairment Alzheimer's & Dementia. Translational Research & Clinical Interventions. 2017, 3(3): 459-470. doi: 10.1016/j.trci.2017.04.008 PMID: 29067352 PMCID: PMC5651427
Hampstead BM, Towler S, Sathian K, Stringer AY. Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume. Alzheimer's & Dementia: Diagnosis, Assessment and Disease Monitoring. 2017. doi: 10.1016/j.dadm.2017.10.007 PMID: 29255787 PMCID: PMC5724745
Huang Z, Zhang H, Boss J, Goutman SA, Mukherjee B, Dinov ID, Guan Y; Pooled Resource Open-Access ALS Clinical Trials Consortium. Complete hazard ranking to analyze right-censored data: An ALS survival study. PLoS Comput Biol. 2017 Dec 18;13(12):e1005887. doi: 10.1371/journal.pcbi.1005887 PMID: 29253881 PMCID: PMC5749893
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR; Alzheimer's Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA.Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2017 Jul 1;13(7):727-38. doi: 10.1016/j.jalz.2016.12.012 PMID: 28183528 PMCID: PMC5496797
Kalinin AA, Palanimalai S, Dinov ID. SOCRAT Platform Design: A Web Architecture for Interactive Visual Analytics Applications. Proceedings of the 2nd Workshop on Human-In-the-Loop Data Analytics. Workshop on Human-In-the-Loop Data Analytics (2nd : 2017 : Chicago, Ill.). 2017 April;2017. PMID: 29630069 PMCID: PMC5884130
Kelly SC, He B, Perez SE, Ginsberg SD, Mufson EJ, Counts SE. Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease. Acta Neuropathological Communications. 2017 Jan 21, 5(1): 8. doi: 10.1186/s40478-017-0411-2. PMID: 28109312 PMCID: PMC5251221
Kotagal V, Bohnen NI, Müller ML, Frey KA, Albin RL. Cerebral amyloid burden and Hoehn and Yahr stage 3 scoring in Parkinson disease. Journal of Parkinson's disease. 2017 Jan 1;7(1):143-7. doi: 10.3233/JPD-160985 PMID: 28106566 PMCID: PMC5470115
Langa KM, Larson EB, Crimmins EM, Faul JD, Levine DA, Kabeto MU, Weir DR. A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012. JAMA Internal Medicine. 2017 Jan 1,177(1): 51-58. doi: 10.1001/jamainternmed.2016.6807. PMID: 27893041 PMCID: PMC5195883
Larson EB, Langa KM. What's the "Take Home" from Research on Dementia Trends? PLoS Med. 2017 Mar 7, 14(3): e1002236. doi: 10.1371/journal.pmed.1002236. PMID: 28267775 PMCID: PMC5340344
Lichtenberg PA, Ocepek-Welikson K, Ficker LJ, Gross E, Rahman-Filipiak A, Teresi JA. Conceptual and empirical approaches to financial decision-making by older adults: Results from a financial decision-making rating scale. Clinical gerontologist. 2018 Jan 1;41(1):42-65. doi: 10.1080/07317115.2017.1367748 PMID: 29077531 PMCID: PMC5766370
Lichtenberg P, Teresi JA, Ocepek-Welikson K, JosEimicke JP. Reliability and Validity of the Lichtenberg Financial Decision Screening Scale. Innovation in Aging. 2017 Mar 1, 00(00): 1–9. doi: 10.1093/geroni/igx003. PMID: 29034335 PMCID: PMC5637552
Lin M, Gong P, Yang T, Ye J , Albin RL, Dodge HH. Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer's Disease and Associated Disorders. 2017. doi: 10.1097/WAD.0000000000000228 PMID: 29227306 PMCID: PMC5854492
Lindauer A, Seelye A, Lyons B, Dodge HH, Mattek N, Mincks K, Kaye J, Erten-Lyons D. Dementia Care Comes Home: Patient and Caregiver Assessment via Telemedicine. Gerontologist. 2017 Oct 1, 57(5): e85-e93. doi: 10.1093/geront/gnw206. PMID: 28158415 PMCID: PMC5654345
Luo L, Wang J, Lo RY, Figueroa KP, Pulst SM, Kuo PH, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH. The Initial Symptom and Motor Progression in Spinocerebellar Ataxias. Cerebellum (London, England). 2017 June;16(3):615-622. doi: 10.1007/s12311-016-0836-3 PMID: 27848087 PMCID: PMC5429172
Ma X, Bai Y, Lin Y, Hong X, Liu T, Ma L, Haacke EM, Zhou J, Wang J, Wang M. Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging. Scientific Reports. 2017 Apr 4, 7: 45696. doi: 10.1038/srep45696. PMID: 28374764 PMCID: PMC5379544
Maust DT, Langa KM, Blow FC, Kales HC. Psychotropic use and associated neuropsychiatric symptoms among patients with dementia in the USA. International Journal of Geriatric Psychiatry. 2017 Feb, 32(2): 164-174. doi: 10.1002/gps.4452. PMID: 26889640 PMCID: PMC4990518
McEvoy CT, Guyer H, Langa KM, Yaffe K. Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. Journal of the American Geriatrics Society. 2017 August;65(8):1857-1862. doi: 10.1111/jgs.14922 PMID: 28440854 PMCID: PMC5633651
McKay E and Counts SE. Multi-infarct dementia: a historical perspective. Dementia and Geriatric Cognitive Disorders Extra. 2017 Jan-Apr, 7(1): 160 - 171. doi: 10.1159/000470836. PMID: 28626470 PMCID: PMC5471781
Ostergren JE, Heeringa SG, Mendes de Leon CF, Connell CM, Roberts JS*. The influence of psychosocial and cognitive factors on perceived threat of Alzheimer’s disease. American Journal of Alzheimer’s Disease & Other Dementias. 2017. 32(5), 289-99. doi: 10.1177/1533317517714552. PMID: 28605999 PMCID: PMC5886712
Park SK, Hong JY, Arslan F, Kanneganti V, Patel B, Tietsort A, Tank EMH, Li X, Barmada SJ, Liebman SW. Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis. PLoS genetics. 2017 May;13(5):e1006805. doi: 10.1371/journal.pgen.1006805 PMID: 28531192 PMCID: PMC5460882
Poey JL, Burr JA, Roberts JS. Social connectedness, perceived isolation, and dementia: Does the social environment moderate the relationship between genetic risk and cognitive well-being? The Gerontologist. 2017. 57(6), 1031-40. doi: 10.1093/geront/gnw154. PMID: 28329797
Pressler SJ, Harrison JM, Titler M, Koelling TM, Jung M, Dorsey SG, Bakoyannis G, Riley PL, Hoyland-Domenico L, Giordani B. APOE ε4 and Memory among Patients with Heart Failure. Western Journal of Nursing Research. 2017, 39(4): 455-472. doi: 10.1177/0193945916670145 PMID: 27733670
Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, *Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017 Mar 21, 14(3): e1002254. doi: 10.1371/journal.pmed.1002254. PMID: 28323826 PMCID: PMC5360223
Ramsey CM, Gnjidic D, Agogo GO, Allore H, Moga D. Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y). 2017 Nov 26;4:1-10. doi: 10.1016/j.trci.2017.10.008 PMID: 29296658 PMCID: PMC5738721
Ryan KA, Hammers D, DeLeon A, Bilen H, Frey K, Burke J, Albin R, Barbas N, Heidebrink J, Giordani B. Agreement among neuropsychological and behavioral data and PiB findings in diagnosing Frontotemporal Dementia. Journal of Clinical Neuroscience. 2017 Jun 7. pii: S0967-5868(17)30253-9. doi: 10.1016/j.jocn.2017.05.008. PMCID: PMC5581998 PMID: 28601570
Sims R, Van Der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature genetics. 2017 Sep;49(9):1373. doi: 10.1038/ng.3916 PMID: 28714976 PMCID: PMC5669039
Song W, Woon FL, Doong A, Persad C, Tijerina L, Pandit P, Cline C, Giordani B. Fatigue in Younger and Older Drivers: Effectiveness of an Alertness Maintaining Task. Human Factors. 2017 Sept, 59(6): 995–1008. doi: 10.1177/0018720817706811 PMID: 28510495
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity. Nature. 2017 December 14;552(7684):187-193. doi: 10.1038/nature25143 PMID: 29211722 PMCID: PMC5730497
Stelmokas J, Yassay L, Giordani B, Dodge HH, Dinov ID, Bhaumik A, Sathian K, Hampstead BM. Translational MRI Volumetry with NeuroQuant: Effects of Version and Normative Data on Relationships with Memory Performance in Healthy Older Adults and Patients with Mild Cognitive Impairment. Journal of Alzheimer's Disease. 2017, 60; 1499-1510. doi: 10.3233/JAD-170306 PMID: 29060939 PMCID: PMC5858697
Tarraf W, Rodríguez CJ, Daviglus ML, Lamar M, Schneiderman N, Gallo L, Talavera GA, Kaplan RC, Fornage M, Conceicao A, González HM. Blood Pressure and Hispanic/Latino Cognitive Function: Hispanic Community Health Study/Study of Latinos Results. Journal of Alzheimer's disease : JAD. 2017;59(1):31-42. doi: 10.3233/JAD-170017 PMID: 28582859 PMCID: PMC5567691
Teresi JA, Ocepek-Welikson K, Lichtenberg PA. Item response theory analysis of the Lichtenberg Financial Decision Screening Scale. Journal of elder abuse & neglect. 2017 August;29(4):213-228. doi: 10.1080/08946566.2017.1338170 PMID: 28590882 PMCID: PMC5608641
Vega IE, Cabrera LY, Wygant CM, Velez-Ortiz D, Counts SE. Alzheimer's Disease in the Latino Community: Intersection of Genetics and Social Determinants of Health. J Alzheimers Dis. 2017. 58(4):979-992. doi: 10.3233/JAD-161261 PMID: 28527211 PMCID: PMC5874398.
Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, Giordani B, Kramer J, Loewenstein D, Marson D, Mungas D, Salmon D, Welsh-Bohmer K, Zhou X-H, Shirk SD, Atri A, Kukull WA, Phelps C, Morris JC. Version 3 of the Alzheimer's Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS) Change. Alzheimer Disease and Associated Disorders. 2017. doi: 10.1097/WAD.0000000000000223 PMID: 29240561 PMCID: PMC5821520
Yeh AN, Pressler S, Algasse D, Struble L, Giordani B. Integrative review of the relationship between sleep disturbances and episodic memory in older adults, Biological Research for Nursing, Accepted for Publication, 2017.2016
Karlawish J, Langa KM. Unfinished Business in Preventing Alzheimer Disease. JAMA internal medicine. 2016 December 1;176(12):1739-1740. doi: 10.1001/jamainternmed.2016.6310 PMID: 27749947 PMCID: PMC5458728
Counts SE, He B, Prout JG, Michalski B, Farotti L, Fahnestock M, Mufson EJ. Cerebrospinal Fluid proNGF: A Putative Biomarker for Early Alzheimer's Disease. Current Alzheimer research. 2016;13(7):800-8. PMID: 26825093
Monsell SE, Dodge HH, Zhou X, Bu Y, Besser LM, Mock C, Hawes SE, Kukull WA, Weintraub S. Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study. Alzheimer Disease & Associated Disorders. 2016 Apr-Jun, 30(2): 134-139. doi: 10.1097/WAD.0000000000000111 PMID: 26485498 PMCID: PMC4834278
Ivo D. Dinov. Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data. GigaScience. 2016 Dec, 5(1): 1-15. doi: 10.1186/s13742-016-0117-6 PMID: 26918190 PMCID: PMC4766610
Hammers D, Ramirez G, Persad C, Heidebrink J, Barbas N, Giordani B. Diagnostic profiles of patients differentially failing executive functioning measures. American Journal of Alzheimer’s Disease & Other Dementias. 2016, 31(3): 214-222. doi: 10.1177/1533317515603114 PMID: 26340963
Kavcic V, Zalar B, Giordani B. The relationship between baseline EEG spectra power and memory performance in older African Americans endorsing cognitive concerns in a community setting. International Journal of Psychophysiology. 2016, 109: 116-123. doi: 10.1016/j.ijpsycho.2016.09.001 PMID: 27613569
Votruba KL, Persad C, Giordani B. Cognitive deficits in healthy elderly population with “normal” scores on the mini-mental state examination. Journal of Geriatric Psychiatry and Neurology. 2016, 29(3): 126-132. doi: 10.1177/0891988716629858 PMID: 26850856
Dodge HH, Zhu J, Woltjer R, Nelson PT, Bennett DA, Cairns NJ, Fardo DW, Kaye JA, Lyons DE, Mattek N, Schneider JA, Silbert LC, Xiong C, Yu L, Schmitt FA, Kryscio RJ, Abner EL. Risk of incident clinical diagnosis of Alzheimer’s disease-type dementia attributable to pathology-confirmed vascular disease. SMART data consortium. Alzheimers Dement. 2016 Dec 23, 13(6): 613-623. pii: S1552-5260(16)33091-6. doi: 10.1016/j.jalz.2016.11.003 PMID: 28017827 PMCID: PMC5466467
Krans A, Kearse MG, Todd PK.Repeat-associated non-AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome. Ann Neurol. 2016 Dec, 80(6): 871-881. doi: 10.1002/ana.24800 PMID: 27761921 PMCID: PMC5177492
Chun SY, Rodriguez CM, Todd PK, Mills RE. SPECtre: a spectral coherence—based classifier of actively translated transcripts from ribosome profiling sequence data. BMC Bioinformatics. 2016 Nov 25, 17(1): 482. doi: 10.1186/s12859-016-1355-4 PMID: 27884106 PMCID: PMC5123373
Flores BN, Dulchavsky ME, Krans A, Sawaya MR, *Paulson HL, Todd PK, Barmada SJ, Ivanova MI. Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.PLoS One. 2016 Oct 24, 11(10): e0165084. doi: 10.1371/journal.pone.0165084 PMID: 27776165 PMCID: PMC5077081
Amiri S, *Dinov ID. Comparison of genomic data via statistical distribution. J Theor Biol. 2016 Oct 21, 407: 318-27. doi: 10.1016/j.jtbi.2016.07.032 PMID: 27460589 PMCID: PMC5361063
Dodge HH, Zhu J, Hughes TF, Snitz BE, Chang CH, Jacobsen EP, Ganguli M.Cohort effects in verbal memory function and practice effects: a population-based study.* Int Psychogeriatr. 2017 Jan, 29(1): 137-148. doi: 10.1017/S1041610216001551 PMID: 27725002 PMCID: PMC5177461
Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T, Mourdoukoutas AP, Kronberg G, Truong D, Boggio P, Brunoni AR, Charvet L, Fregni F, Fritsch B, Gillick B, Hamilton RH, *Hampstead BM, Jankord R, Kirton A, Knotkova H, Liebetanz D, Liu A, Loo C, Nitsche MA, Reis J, Richardson JD, Rotenberg A, Turkeltaub PE, Woods AJ. Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016. Brain Stimul. 2016 Sep-Oct, 9(5): 641-61. doi: 10.1016/j.brs.2016.06.004. PMID: 27372845 PMCID: PMC5007190
Zhu F, Panwar B, *Dodge HH, Li H, *Hampstead BM, *Albin RL,* Paulson HL, Guan, Y.COMPASS: A computational model to predict changes in MMSE scores 24-months after initial assessment of Alzheimer's disease. Sci Rep. 2016 Oct 5, 6: 34567. doi: 10.1038/srep34567 PMID: 27703197 PMCID: PMC5050516
Zhang J, Shi J, Stonnington C, Li Q, Gutman BA, Chen K, Reiman EM, Caselli RJ, Thompson PM, Ye J, Wang Y. Hyperbolic Space Sparse Coding with Its Application on Prediction of Alzheimer's Disease in Mild Cognitive Impairment. Medical Image Comput Comput Assist Interv. 2016 Oct, 9900: 326-334. doi: 10.1007/978-3-319-46720-7_38 PMID: 28066843 PMCID: PMC5217478
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. Dominantly Inherited Alzheimer Network. PLoS One. 2016 Sep 20, 11(9): e0163669. doi: 10.1371/journal.pone.0163669 PMID: 27649320 PMCID: PMC5029931
Mufson EJ, Ikonomovic MD, Counts SE, Perez SE, Malek-Ahmadi M, Scheff SW, Ginsberg SD. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioral Brain Research. 2016 Sep 15, 311: 54-69. doi: 10.1016/j.bbr.2016.05.030 PMID: 27185734 PMCID: PMC4931948
Gawronski KA, Kim ES, Langa KM, Kubzansky LD. Dispositional Optimism and Incidence of Cognitive Impairment in Older Adults. Psychosomatic Medicine. 2016 Sep, 78(7): 819-28. doi: 10.1097/PSY.0000000000000345 PMID: 27284699 PMCID: PMC5349707
Díaz-Venegas C, Downer B, Langa KM, Wong R. Racial and ethnic differences in cognitive function among older adults in the USA. International Journal of Geriatric Psychiatry. 2016 Sep, 31(9): 1004-12. doi: 10.1002/gps.4410 PMID: 26766788 PMCID: PMC4945484
Promjunyakul NO, Lahna DL, Kaye JA, *Dodge HH, Erten-Lyons D, Rooney WD, Silbert LC.Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities: A multi-modal magnetic resonance imaging study. Journal of Cerebral Blood Flow Metabolism. 2016 Sep, 36(9): 1528-36. doi: 10.1177/0271678X16651268. Epub 2016 Jun 7. doi: 10.1177/0271678X16651268 PMID: 27270266 PMCID: PMC5010096
Reams N, Eckner JT, Almeida AA, Aagesen AL, *Giordani B, *Paulson H, Lorincz MT, Kutcher JS. A clinical approach to the diagnosis of traumatic encephalopathy syndrome: A review. Journal of the American Medical Association: Neurology. 2016, 73(6): 734-749. doi: 10.1001/jamaneurol.2015.5015 PMID: 27111824 PMCID: PMC49220022015
Gabel NM, Crane NA, Avery ET, Kay RE, Laurent A, Giordani B, Alexander NB, Weisenbach SL. Dual-tasking gait variability and cognition in late-life depression. Int J Geriatr Psychiatry. 2015 Nov, 30(11): 1120-8. doi: 10.1002/gps.4340 PMID: 26251013
Albin RL, Fisher-Hubbard A, Shanmugasundaram K, Koeppe RA, Burke JF, Camelo-Piragua S, Lieberman AP, Giordani B, Frey KA. Post-mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications. Ann Neurol. 2015 Nov, 78(5): 824-30. doi: 10.1002/ana.24481. PMID: 26183692 PMCID: PMC4836870
Mufson EJ, Mahady L, Waters D, Counts SE, Perez SE, DeKosky ST, Ginsberg SD, Ikonomovic MD, Scheff SW, Binder L. Hippocampal plasticity during the progression of Alzheimer’s disease. Neuroscience. 2015 Nov 19, 309: 51-67. doi: 10.1016/j.neuroscience.2015.03.006. PMID: 25772787 PMCID: PMC4567973
Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Lam LC, Wong CH, Fung AW, Guaita A, Vaccaro R, Davin A, Ganguli M, Dodge H1, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration. PLoS One. 2015 Nov 5, 10(11): e0142388. doi: 10.1371/journal.pone.0142388 PMID: 26539987 PMCID: PMC4634954
Friedman EM, Shih RA, Langa KM, Hurd MD.US prevalence and predictors of informal caregiving for dementia. Health Aff (Millwood). 2015 Oct, 34(10): 1637-41. doi: 10.1377/hlthaff.2015.0510 PMID: 26438738 PMCID: PMC4872631
Beach PA, Huck JT, Miranda MM, Bozoki AC. Autonomic, behavioral, and subjective pain responses in Alzheimer’s disease. Pain Med. 2015 Oct;16(10):1930-42. doi: 10.1111/pme.12769 PMID: 25929320
Beach PA, Huck JT, Miranda MM, Bozoki AC. Factors associated with cognitive evaluations in the United States. Pain Med. 2015 Oct, 16(10): 1930-42. doi: 10.1111/pme.12769 PMID: 25929320 PMCID: PMC4336093
Lichtenberg PA, Ficker LJ, Rahman-Filipiak A. Financial decision-making abilities and exploitation in older African Americans: Preliminary validity evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS). J Elder Abuse Negl. 2016, 28(1): 14-33. doi: 10.1080/08946566.2015.1078760 PMID: 26285038 PMCID: PMC4740256
Oh SY, He F, Krans A, Frazer M, Taylor JP, Paulson HL, Todd PK. RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Hum Mol Genet. 2015 Aug 1, 24(15): 4317-26. doi: 10.1093/hmg/ddv165 PMID: 25954027 PMCID: PMC4492395
Votruba KL, Persad C, Giordani B. Patient mood and instrumental activities of daily living in Alzheimer disease: Relationship between patient and caregiver reports. J Geriatr Psychiatry Neurol. 2015 Sep, 28(3): 203-9. doi: 10.1177/0891988715588829 PMID: 26071443
Levine DA, Galecki AT, Langa K3, Unverzagt FW, Kabeto MU, Giordani B, Wadley VG. Trajectory of cognitive decline after incident stroke. JAMA. 2015 Jul 7, 314(1): 41-51. doi: 10.1001/jama.2015.6968 PMID: 26151265 PMCID: PMC4655087
Kotagal V, Bohnen NI, Müller ML, Koeppe RA, Frey KA, Langa KM, Albin RL. Educational attainment and motor burden in Parkinson’s disease. Mov Disord. 2015 Jul, 30(8): 1143-7. doi: 10.1002/mds.26272 PMID: 26096339 PMCID: PMC4504749
Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A. 2015 Jun 23, 112(25): 7821-6. doi: 10.1073/pnas.1509744112 PMID:26056265 PMCID: PMC4485101
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium; GERAD1 Consortium; EPIC-InterAct Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Associations between potentially modifiable risk factors and Alzheimer disease: A Mendelian Randomization Study. PLoS Med. 2015 Jun 16, 12(6): e1001841; discussion e1001841. doi: 10.1371/journal.pmed.1001841 PMID: 26079503 PMCID: PMC4469461
Fyock CA, Hampstead BM. Comparing the relationship between subjective memory complaints, objective memory performance, and medial temporal lobe volumes in patients with mild cognitive impairment. Alzheimers Dement (Amst). 2015 Jun 1, 1(2): 242-248. doi: 10.1016/j.dadm.2015.03.002 PMID: 26191540 PMCID: PMC4501028
Monsell SE, Dodge HH, Zhou XH, Bu Y, Besser LM, Mock C, Hawes SE, Kukull WA, Weintraub S; Neuropsychology Work Group Advisory to the Clinical Task Force. Results from the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study. Alzheimer Dis Assoc Disord. 2016 Apr-Jun, 30(2): 134-9. doi: 10.1097/WAD.0000000000000111 PMID: 26485498 PMCID: PMC4834278
Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci. 2015 Apr 15, 35(15): 6165-78. doi: 10.1523/JNEUROSCI.3013-14.2015 PMID: 25878288 PMCID: PMC4397610
Langa KM. Is the risk of Alzheimer’s disease and dementia declining? Alzheimers Res Ther. 2015 Mar 26, 7(1): 34. doi: 10.1186/s13195-015-0118-1 PMID: 25815064 PMCID: PMC4374373
Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA.A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. 2016 Jan, 21(1): 108-17. doi: 10.1038/mp.2015.23. PMID: 25778476 PMCID: PMC4573764
Moon SW, Dinov ID, Kim J, Zamanyan A, Hobel S, Thompson PM, Toga AW. Structural neuroimaging genetics interactions in Alzheimer’s Disease. J Alzheimers Dis. 2015, 48(4): 1051-63. doi: 10.3233/JAD-150335 PMID: 26444770 PMCID: PMC4730943
Beck JS, Mufson EJ, Counts SE. Evidence for mitochondrial UPR gene activation in familial and sporadic Alzheimer’s disease. Curr Alzheimer Res. 2016, 13(6): 610-4. PMID: 26687188
Moon SW, Dinov ID, Zamanyan A, Shi R, Genco A, Hobel S, Thompson PM, Toga AW; Alzheimer's Disease Neuroimaging Initiative (ADNI). Gene interactions and structural brain change in early-onset Alzheimer’s disease subjects using the pipeline environment. Psychiatry Investig. 2015 Jan, 12(1): 125-35. doi: 10.4306/pi.2015.12.1.125 PMID: 25670955 PMCID: PMC4310910
Hampstead BM, Khoshnoodi M, Yan W, Deshpande G, Sathian K.Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults. Neuroimage. 2016 Jan 1, 124(Pt A): 997-1008. doi: 10.1016/j.neuroimage.2015.10.002 PMID: 26458520
Paulson D, Lichtenberg PA. The Paulson-Lichtenberg Frailty Index: evidence for a self-report measure of frailty. Aging Ment Health. 2015, 19(10): 892-901. doi: 10.1080/13607863.2014.986645 PMID: 25537004 PMCID: PMC4480217
Archived StudiesImproving Alertness During Long Drives: A Driving Simulation Study
Principal Investigator (PI): Bruno Giordani, PhD
Co-PI: Carol Persad, PhD
Project Description: This study involves the use of a computerized driving simulator to find out if engaging in simple game-like tasks could promote alertness and improved driving performance in fatigued drivers. The study will take place in 2 separate sessions that will last approximately 2 hours each. Participants will be compensated for their time spent in the study.
Participation Criteria: Persons aged 55-65 years with a valid driver’s license over the past 2 years and driving in past 6 months.NOBLE
Principle Investigator (PI): Judith Heidebrink MD, MS
Project Description: The purpose of this research study is to determine whether an investigational drug, T-817MA (also called “T-817”), is safe and beneficial in delaying or altering the decline in memory and daily functioning when given to people with Alzheimer’s disease (AD). We will also be studying the effect of T-817 on brain magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers. The U.S. Food and Drug Administration (FDA) has not approved T-817 for the treatment of AD and we do not know whether daily use of T-817 can change the course of the disease.
Participant Criteria: Male or female 55-85 years old; have AD and are experiencing memory problems; currently taking a medication (donepezil [Aricept®] or rivastigmine transdermal system (Exelon® Patch) or donepezil or Rivastigmine and memantine [Namenda™]) for the treatment of AD; have brain MRI or CT result consistent with Alzheimer’s disease; residing in the community with a designated study partner who will accompany the patient to all clinic visits and participate in the evaluations (see protocol details). You may NOT qualify for participation in this study if you use any drug other than donepezil or Exelon Patch (with or without memantine) for Alzheimer’s disease, including galantamine (razadyne); have other neurodegenerative diseases, including Parkinson’s disease, Huntington’s disease, or cerebral tumor; have history of untreated thyroid disorder, Type I diabetes, and insulin-dependent, or uncontrolled Type II diabetes, as determined by the PI (except non-insulin controlled Type II diabetes, whose HbA1c value must be below 8.0 %).
Contact: Kathryn Steen MA, email@example.com 734-736-9909Retaining Identity: Creativity and Caregiving
Principle Investigator (PI): Anne Mondro, MFA, Elaine Reed, BFA
Project Description: The goal of our study is to better understand the role of art in the support network of adults with memory loss and their care partners. In the first four weeks, caregivers will learn how to use art materials, explore their creativity, develop a basic understanding of art and design principles, and build communication skills for working with persons with memory loss through art making and guided discussions. Respite care will be available. In the following four weeks, the caregiver will teach the same projects to their care recipient. Facilitators will help guide the caregiver in how to structure the projects for their partner and aid in providing ways to communicate successfully in leading their partner through the art making. A guided discussion with the group will follow. All sessions will be held at the Turner Senior Resource Center in Ann Arbor. Free, close to the building parking is available. Materials and supplies are free to all participants.
Participation Criteria: Diagnosis of mild to moderate Alzheimer’s disease; 50 years of age or over; fluent in English; a study partner/caregiver is required.
Contact: Annie Hyrila, firstname.lastname@example.org, 734-763-3534
Retaining Identity: Creativity and Caregiving brochure (PDF)The WeCareAdvisor Tool to Assist Families Living with Dementia
Principal Investigator (PI): Helen Kales, MD
Project Description: Our study is currently seeking family caregivers to test the WeCareAdvisor, a customized, easy-to-use, internet-based tool that aims to assist in better understanding and managing behavioral symptoms that are a part of dementia. Participants will be interviewed by telephone and then in their home. If it is determined that the study is right for the caregiver and their family member with dementia, they will be randomly assigned to one of two groups that will test the WeCareAdvsior tool for a one-month period. Group A will receive the WeCareAdvisor and begin their trial testing immediately. Group B will test the WeCareAdvisor after a one-month waiting period. During the one month testing period of the WeCareAdvisor participants will also receive weekly check-in phone calls from a research team member. Participants will be compensated for their time spent in the study.
Participation Criteria: The in-home primary caregiver for a person living with dementia, 21 years of age or older, managing behaviors the caregiver finds challenging and comfortable with technology.
Contact: Molly Turnwald, email@example.com, 734-232-0393FYN
Principal Investigator (PI): Judith Heidebrink MD, MS
Project Description: The purpose of this research study is to determine whether AZD0530 is safe and effective in slowing decline in brain metabolism, memory and daily function in people with Alzheimer’s disease. Researchers believe that AZD0530 works by protecting your brain cells from the damage caused by amyloid protein. Amyloid protein is known to be associated with the development of AD. We will use imaging tests to see if AZD0530 affects brain structure and function, and also look at certain proteins in the blood and spinal fluid (the fluid surrounding the brain and spinal cord) that are associated with Alzheimer’s disease.
Participant Criteria: You must be male or female between the ages of 55-85 and have a diagnosis of Alzheimer’s disease. You must be in good general health and be on stable medications. You must have a study partner who is willing to accompany you to your study visits and monitors your study medication and how you are doing on a day to day basis.Merck 19
Principle Investigator (PI): Judith Heidebrink MD, MS
Project Description: The purpose of the study is to test the safety and efficacy of MK-8931 in the treatment of individuals with amnestic Mild Cognitive Impairment due to Alzheimer’s disease (AD). The study will assess the effects that two doses of MK-8931 have on disease progression.
Participation Criteria: Male or female between the ages of 55 and 85; Mild Cognitive Impairment due to Alzheimer’s Disease; a spouse, friend, relative, or caregiver who is willing to accompany them to all of the study visits, monitor them while they are taking the study drug and communicate changes in the patient’s health status over the period of this study.
Contact: Kathryn Steen MA, firstname.lastname@example.org 734-736-9909BAN2401
Principal Investigator (PI): Nancy Barbas MD, MSW
Project Description: The purpose of the BAN2401 research study is to find out if BAN2401 has a positive effect on a person’s cognitive ability based on a series of specialized cognitive tests. The purpose of this research is also to find out if the study drug is safe and well-tolerated in people with early Alzheimer’s disease. People with Alzheimer’s disease have a build-up of abnormal protein known as amyloid in their brains. BAN2401 is thought to reduce the amount of this abnormal protein. The study drug will be given by injecting it into a vein. Analysis will be performed to find out how much of the study drug is in the blood at different times after the injection.
Participation Criteria: Diagnosis of Mild Cognitive Impairment (MCI) or mild Alzheimer’s disease, male or female between the ages of 50 and 90, and ability to provide written consent
Contact: Amanda Rasnake BSN, RN, CCRP, email@example.com 734-232-2452